Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
Journal of Parenteral and Enteral Nutrition
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Salo, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Salo, M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Inhibition of Immunoglobulin Synthesis In Vitro by Intravenous Lipid Emulsion (Intralipid)

M. Salo, M.D.

Departments of Anaesthesiology and Medical Microbiology, University of Turku. Turku. Finland

Intravenous lipid emulsions depress lymphocyte proliferative responses and granulocyte function at concentrations found in the blood circulation during their administration. The effects of Intralipid, a widely used intravenous lipid emulsion, were measured on immunoglobulin production in vitro by pokeweed mitogen-activated lymphocytes as a test of B-cell function. Intralipid decreased IgG, IgM, and IgA production at soybean oil triglyceride concentrations of 2.5-20 mg/ml occurring in the blood circulation during Intralipid infusion. The effects on IgM and IgA production were highest and that on IgG production lowest. Hydrocortisone-sensitive and concanavalin A-inducible suppressor cells were more sensitive to Intralipid than other cell populations. In vivo Ig production may not be equally disturbed, inasmuch as Intralipid concentrations in the lymph nodes and the spleen may be lower than in the blood circulation. However, care should be taken to prevent Intralipid concentrations from becoming high enough to depress immune responses. (Journal of Parenteral and Enteral Nutrition 14:459-462, 1990)

Journal of Parenteral and Enteral Nutrition, Vol. 14, No. 5, 459-462 (1990)
DOI: 10.1177/0148607190014005459
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 JPEN J Parenter Enteral NutrHome page
D. Granato, S. Blum, C. Rossle, J. Le Boucher, A. Malnoe, and G. Dutot
Effects of Parenteral Lipid Emulsions With Different Fatty Acid Composition on Immune Cell Functions In Vitro
JPEN J Parenter Enteral Nutr, March 1, 2000; 24(2): 113 - 118.
[Abstract] [PDF]

Home page
 JPEN J Parenter Enteral NutrHome page
P. S. Hinton, C. A. Peterson, H.-C. Lo, Huan Yang, D. Mccarthy, and D. M. Ney
Insulin-Like Growth Factor-I Enhances Immune Response in Dexamethasone-Treated or Surgically Stressed Rats Maintained With Total Parenteral Nutrition
JPEN J Parenter Enteral Nutr, November 1, 1995; 19(6): 444 - 452.
[Abstract] [PDF]

Home page
 Nutr Clin PractHome page
J. P. Grant
Invited Review: Nutrition Care of Patients With Acute and Chronic Respiratory Failure
Nutr Clin Pract, February 1, 1994; 9(1): 11 - 17.
[Abstract] [PDF]

Home page
 Nutr Clin PractHome page
M. M. Gottschlich
Invited Review: Selection of Optimal Lipid Sources in Enteral and Parenteral Nutrition
Nutr Clin Pract, August 1, 1992; 7(4): 152 - 165.
[Abstract] [PDF]