This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Salo, M. Search for Related Content PubMed PubMed Citation Articles by Salo, M. Pubmed/NCBI databases Substance via MeSH Medline Plus Health Information Dietary Fats Social Bookmarking                         What's this?

Inhibition of Immunoglobulin Synthesis In Vitro by Intravenous Lipid Emulsion (Intralipid)

Departments of Anaesthesiology and Medical Microbiology, University of Turku. Turku. Finland

Intravenous lipid emulsions depress lymphocyte proliferative responses and granulocyte function at concentrations found in the blood circulation during their administration. The effects of Intralipid, a widely used intravenous lipid emulsion, were measured on immunoglobulin production in vitro by pokeweed mitogen-activated lymphocytes as a test of B-cell function. Intralipid decreased IgG, IgM, and IgA production at soybean oil triglyceride concentrations of 2.5-20 mg/ml occurring in the blood circulation during Intralipid infusion. The effects on IgM and IgA production were highest and that on IgG production lowest. Hydrocortisone-sensitive and concanavalin A-inducible suppressor cells were more sensitive to Intralipid than other cell populations. In vivo Ig production may not be equally disturbed, inasmuch as Intralipid concentrations in the lymph nodes and the spleen may be lower than in the blood circulation. However, care should be taken to prevent Intralipid concentrations from becoming high enough to depress immune responses. (Journal of Parenteral and Enteral Nutrition 14:459-462, 1990)

Journal of Parenteral and Enteral Nutrition, Vol. 14, No. 5, 459-462 (1990)
DOI: 10.1177/0148607190014005459


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				D. Granato, S. Blum, C. Rossle, J. Le Boucher, A. Malnoe, and G. Dutot Effects of Parenteral Lipid Emulsions With Different Fatty Acid Composition on Immune Cell Functions In Vitro JPEN J Parenter Enteral Nutr, March 1, 2000; 24(2): 113 - 118. [Abstract] [PDF]

				P. S. Hinton, C. A. Peterson, H.-C. Lo, Huan Yang, D. Mccarthy, and D. M. Ney Insulin-Like Growth Factor-I Enhances Immune Response in Dexamethasone-Treated or Surgically Stressed Rats Maintained With Total Parenteral Nutrition JPEN J Parenter Enteral Nutr, November 1, 1995; 19(6): 444 - 452. [Abstract] [PDF]

				J. P. Grant Invited Review: Nutrition Care of Patients With Acute and Chronic Respiratory Failure Nutr Clin Pract, February 1, 1994; 9(1): 11 - 17. [Abstract] [PDF]

				M. M. Gottschlich Invited Review: Selection of Optimal Lipid Sources in Enteral and Parenteral Nutrition Nutr Clin Pract, August 1, 1992; 7(4): 152 - 165. [Abstract] [PDF]