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Journal of Parenteral and Enteral Nutrition
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Case Reports

Manganese Levels in a Jaundiced Long-Term Total Parenteral Nutrition Patient: Potentiation of Haloperidol Toxicity?: Case Report and Literature Review

Rehka Mehta, M.D.

Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

James J. Reilly, M.D.

Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

Manganese is vital in human nutrition. When oral intake is precluded, the recommended parenteral supplementation is 0.15 to 0.8 mg/day. Manganese is excreted primarily in the bile; during cholestasis, serum manganese levels may rise, and manganese toxicity ensue. Neuropsychiatric symptoms are prominent. Phenothiazine-derivative drugs may potentiate manganese toxicity. Serum or whole blood manganese levels should guide manganese therapy in jaundiced patients. (Journal of Parenteral and Enteral Nutrition 14 :428-430, 1990)

Journal of Parenteral and Enteral Nutrition, Vol. 14, No. 4, 428-430 (1990)
DOI: 10.1177/0148607190014004428
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