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Vitamin E Suppresses Increased Lipid Peroxidation in Cigarette Smokers

Division of Gastroenterology, Toronto General Hospital and the Department of Medicine, University of Toronto, Toronto, Ontario, Canada

Riaz Shariff, M.D.

Division of Gastroenterology, Toronto General Hospital and the Department of Medicine, University of Toronto, Toronto, Ontario, Canada

Andre Van Gossum, M.D.

Division of Gastroenterology, Toronto General Hospital and the Department of Medicine, University of Toronto, Toronto, Ontario, Canada

Johane P. Allard, M.D.

Division of Gastroenterology, Toronto General Hospital and the Department of Medicine, University of Toronto, Toronto, Ontario, Canada

Claude Pichard, M.D., PH.D.

Division of Gastroenterology, Toronto General Hospital and the Department of Medicine, University of Toronto, Toronto, Ontario, Canada

Regina Kurian, R.T.

Division of Gastroenterology, Toronto General Hospital and the Department of Medicine, University of Toronto, Toronto, Ontario, Canada

Khursheed N. Jeejeebhoy, M.B., B.S., PH.D.

Division of Gastroenterology, Toronto General Hospital and the Department of Medicine, University of Toronto, Toronto, Ontario, Canada

Cigarette smoke contains many xenobiotics, including oxidants and free radicals, which can increase lipid peroxidation. Recently, breath pentane output (BPO) has been recognized as a good indicator of lipid peroxidation.

Vitamin E is known to be a potent free radical scavenger which can protect biological membranes against oxidative damage. We investigated the effect of vitamin E (dl-alpha-tocopherol) on lipid peroxidation in 13 healthy smokers. The results showed (1) smokers had increased BPO as compared with 19 healthy non-smokers (16.3 ± 1.9 us 5.8 ± 0.5, pmol/kg body weight/min, p < 0.001 ) although both groups had comparable plasma vitamin E and selenium concentrations, (2) supplementation with vitamin E (800 mg/day for 2 weeks) decreased BPO in smokers, and (3) the concentration of plasma selenium-dependent glutathione peroxidase was restored to normal in those smokers (five out of 13) in whom this was low initially.

We conclude that a normal plasma concentration of vitamin E does not prevent this increase of lipid peroxidation in smokers but that substantial doses of vitamin E will significantly reduce this increased lipid peroxidation. If a major function of vitamin E is to protect lipids from peroxidation, then smokers have a conditioned insufficiency of vitamin E on a normal diet. (Journal of Parenteral and Enteral Nutrition 14:300-305, 1990)

Journal of Parenteral and Enteral Nutrition, Vol. 14, No. 3, 300-305 (1990)
DOI: 10.1177/0148607190014003300


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