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Response of Preterm Infants to Aluminum in Parenteral NutritionUniversity of Alberta, Edmonton, Alberta, Canada
University of Cincinnati Medical Center, Children's Hospital Medical Center, Children's Hospital Research Foundation and Clinical Research Center, University of Cincinnati, Ohio
University of Cincinnati Medical Center, Children's Hospital Medical Center, Children's Hospital Research Foundation and Clinical Research Center, University of Cincinnati, Ohio
University of Cincinnati Medical Center, Children's Hospital Medical Center, Children's Hospital Research Foundation and Clinical Research Center, University of Cincinnati, Ohio
University of Cincinnati Medical Center, Children's Hospital Medical Center, Children's Hospital Research Foundation and Clinical Research Center, University of Cincinnati, Ohio Twenty-five preterm infants with birth weights (BW) 540 to 2280 g (20 with birth weight < 1500 g) and gestational ages 24 to 37 weeks, were studied to determine the response to 2 levels of aluminum (Al) loading from currently unavoidable contamination of various components of parenteral nutrition (PN) solution. High Al loading group (H) received solutions with measured Al content of 306 ± 16 µg/liter and low A1 loading group (L) received solutions with 144 ± 16 µg A1/liter. Urine Al:Creatinine (Al:Cr) ratios (µg:mg) became elevated and significantly higher in H (1.6 ± 0.38 us 0.5 ± 0.1, p < 0.05) at the third sampling point (mean 19 days). Serum Al concentrations were highest at onset in both groups and stabilized with study but remained consistently higher than the normal median of 18 µg/liter. Calculated urine Al excretion were consistently low and were 34 ± 6% us 28 ± 5% in the H and L groups, respectively. One infant in the L group who died 39 days after termination of above study showed the presence of A1 in bone trabeculae and the presence of excessive unmineralized osteoid along the trabeculae. We conclude that small preterm infants are able to increase urine Al excretion with increased Al load. However urine Al excretion is incomplete with bone deposition of Al and persistently elevated serum Al concentrations. (Journal of Parenteral and Enteral Nutrition 13:516-519, 1989)
Journal of Parenteral and Enteral Nutrition, Vol. 13, No. 5,
516-519 (1989) This article has been cited by other articles:
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