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Effect of Administered Human Growth Hormone on Protein Metabolism in Septic Rats

Kumamoto University Medical School, Kumamoto, Japan

Toshitada Okuma, M.D.

Kumamoto University Medical School, Kumamoto, Japan

Yoichi Tabira, M.D.

Kumamoto University Medical School, Kumamoto, Japan

Yoshimasa Miyauchi, M.D.

Kumamoto University Medical School, Kumamoto, Japan

The effect of administered human growth hormone (hGH) on protein metabolism in septic rats was investigated. Fifty-three male Wistar rates with SVC cannulation were divided into four groups. Group I (n = 10) underwent sham-operation. Sepsis was induced by cecal ligation in group II (n = 19), group III (n = 10), and group IV (n =14). Isocaloric, isonitrogenous glucose/amino acids were infused for 4 days. hGH was administered in group III (100 mU/day) and group IV (200 mU/day) every day. Cumulative nitrogen balance (mg/ kg) in group IV was significantly higher than in group II (p < 0.01): group I, 1264 ± 355; group II, 117 ± 693; group III, 92 ± 735; group IV, 1001 ± 279. Cumulative urinary excretion of 3-methylhistidine (3-MH, mg/kg) did not differ between group II and group IV: group I, 6.2 ± 0.9; group II, 12.0 ± 2.2; group III, 13.4 ± 2.9; group IV, 10.5 ± 2.3. Serum albumin level in group IV (1.8 ± 0.2 g/dl) was significantly higher than in group II (1.5 ± 0.2 g/dl) (p < 0.01). Blood urea nitrogen level in group IV (12.6 ± 2.3 mg/dl) was significantly lower than in group II (18.8 ± 7.4 mg/dl) (p < 0.05). Although serum levels of glucose, insulin, triglyceride, and phospholipid were higher in sepsis groups than in sham-operated group, those levels did not differ among sepsis groups. Administration of hGH, 200 mU/day, resulted in marked nitrogen retention and had little effect on 3-MH excretion. These data suggest that exogenously administered growth hormone mainly favors the conservation of visceral protein compartment in the septic state. (Journal of Parenteral and Enteral Nutrition 13:450-454, 1989)

Journal of Parenteral and Enteral Nutrition, Vol. 13, No. 5, 450-454 (1989)
DOI: 10.1177/0148607189013005450


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