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Journal of Parenteral and Enteral Nutrition
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Case Reports

Serial Plasma and Urinary Aluminum Levels and Tissue Loading in Preterm Twins

Mary Ellen A. Bozynski, M.D.

Uniaersity of Michigan Medical Center, Department of Pediatrics, Ann Arbor, Michigan

Aileen B. Sedman, M.D.

Uniaersity of Michigan Medical Center, Department of Pediatrics, Ann Arbor, Michigan

Ronald A. Naglie, M.D.

University of California-Irvine Medical Center, Irvine, California

Eileen J. Wright, C.N.S.

Uniaersity of Michigan Medical Center, Department of Pediatrics, Ann Arbor, Michigan

Serial plasma, urinary, and postmortem tissue aluminum levels were determined in 32-week, appropriate-forgestational-age twins from 45 to 151 days postnatal age. Estimated total aluminum absorptions were 56.7 mg, and 28 mg, twin A and twin B, respectively.

At autopsy, Twin A had a hypoplastic right kidney while Twin B had normal kidneys. Mean plasma aluminum levels (twin A, 34.2 µg/liter and twin B, 32.3 µg/liter) and urinary aluminum levels expressed as aluminum creatinine ratios (twin A, 11.3 and twin B, 8.5) were similar. These levels were elevated compared to normal plasma aluminum levels of 5.1 ± 3.6 (1 SD) and urinary aluminum creatinine ratios of 0.64 ± 0.75 (1 SD). Twin A had higher tissue aluminum levels than twin B in all tissues except for brain. Bone and liver aluminum contents for both twins were increased as compared to infants receiving short-term or no parenteral nutrition. We conclude; (1) tissue aluminum loading occurs in infants receiving aluminum-containing solutions, (2) plasma and urinary aluminum levels are poor predictors of tissue aluminum content, (3) enteral solutions may add significant aluminum exposure. (Journal of Parenteral and Enteral Nutrition 13:428-431, 1989)

Journal of Parenteral and Enteral Nutrition, Vol. 13, No. 4, 428-431 (1989)
DOI: 10.1177/0148607189013004428
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Home page
 JPEN J Parenter Enteral NutrHome page
D. Bougle, F. Bureau, J. Voirin, D. Neuville, and J.F. Duhamel
A Cross-Sectional Study of Plasma and Urinary Aluminum Levels in Term and Preterm Infants
JPEN J Parenter Enteral Nutr, March 1, 1992; 16(2): 157 - 159.
[Abstract] [PDF]