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Copper Deficiency during Total Parenteral Nutrition: Clinical Analysis of Three Cases

First Department of Surgery and Department of Pediatric Surgery, Osaka Uniuersity Medical School, Osaka, Japan

Takeo Itakura, M.D.

First Department of Surgery and Department of Pediatric Surgery, Osaka Uniuersity Medical School, Osaka, Japan

Yoji Takagi, M.D.

First Department of Surgery and Department of Pediatric Surgery, Osaka Uniuersity Medical School, Osaka, Japan

Akira Okada, M.D.

First Department of Surgery and Department of Pediatric Surgery, Osaka Uniuersity Medical School, Osaka, Japan

Three adult cases in which copper deficiency developed during long-term total parenteral nutrition (TPN) without copper supplementation have been described, together with a brief review of the literature. All three patients were suffering from malabsorption when TPN was instituted, and overt symptoms of copper deficiency developed an average of 5.8 months after the start of TPN. Clinically, leukopenia with neutropenia and low plasma levels of copper and ceruloplasmin were seen in all cases. The dosage of copper administration in these cases was 0.3 to 7.2 mg of copper/day, or 5.3 to 133 µg of copper/kg/day, with total doses of 7 to 176 mg of copper. (Journal of Parenteral and Enteral Nutrition 13:421-425, 1989)

Journal of Parenteral and Enteral Nutrition, Vol. 13, No. 4, 421-425 (1989)
DOI: 10.1177/0148607189013004421


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