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Journal of Parenteral and Enteral Nutrition
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*Crohn's Disease
*Diets
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Remission Induction in Refractory Crohns Disease Using a High Calorie Whole Diet

N.H. Afdhal, M.D.

Gastroenterology and Liver Unit, St. Vincents Hospital and University College Dublin, Ireland

J. Kelly

Gastroenterology and Liver Unit, St. Vincents Hospital and University College Dublin, Ireland

P.A. Mccormick, M.D.

Gastroenterology and Liver Unit, St. Vincents Hospital and University College Dublin, Ireland

D.P. O'Donoghue, M.D., F.R.C.P.

Gastroenterology and Liver Unit, St. Vincents Hospital and University College Dublin, Ireland

Eleven patients with severe refractory Crohns disease were treated with a high calorie, whole diet. Eight patients achieved remission with a drop in DAS from 13 to 4 (t = 6.31, p < 0.001) and reversal of subacute obstruction in all cases. Nutritional parameters including weight, triceps skinfold thickness, arm muscle area, and serum albumin increased in all patients. The diet was well tolerated with a mean treatment period of 20 days. Clinical relapse of disease occurred in all cases within 9 months (mean 6 ± 2 months). The mechanism of action of a high calorie diet (HCD) is unclear and warrants further study but antigen or specific food exclusion does not appear to be required as judged by this study. (Journal of Parenteral and Enteral Nutrition 13:362-365, 1989)

Journal of Parenteral and Enteral Nutrition, Vol. 13, No. 4, 362-365 (1989)
DOI: 10.1177/0148607189013004362
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