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Journal of Parenteral and Enteral Nutrition
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Pentobarbital Improves Nitrogen Retention in Sepsis

Roland N. Dickerson, PHARM.D.

Department of Surgery, University of Pennsylvania School of Medicine, Pharmacy and Drug Information Service, Hospital of the University of Pennsylvania, Philadelphia Veterans Administration Medical Center, Philadelphia, Pennsylvania, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey

Robert C. Fried, M.D.

Department of Surgery, University of Pennsylvania School of Medicine, Pharmacy and Drug Information Service, Hospital of the University of Pennsylvania, Philadelphia Veterans Administration Medical Center, Philadelphia, Pennsylvania, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey

Melba Gibson Daniel, PHARM.D.

Department of Surgery, University of Pennsylvania School of Medicine, Pharmacy and Drug Information Service, Hospital of the University of Pennsylvania, Philadelphia Veterans Administration Medical Center, Philadelphia, Pennsylvania, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey

T. Peter Stein, PH.D.

Department of Surgery, University of Pennsylvania School of Medicine, Pharmacy and Drug Information Service, Hospital of the University of Pennsylvania, Philadelphia Veterans Administration Medical Center, Philadelphia, Pennsylvania, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey

James L. Mullen, M.D.

Department of Surgery, University of Pennsylvania School of Medicine, Pharmacy and Drug Information Service, Hospital of the University of Pennsylvania, Philadelphia Veterans Administration Medical Center, Philadelphia, Pennsylvania, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey

Gordon P. Buzby, M.D.

Department of Surgery, University of Pennsylvania School of Medicine, Pharmacy and Drug Information Service, Hospital of the University of Pennsylvania, Philadelphia Veterans Administration Medical Center, Philadelphia, Pennsylvania, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey

Pentobarbital therapy has been associated with decreased urinary nitrogen excretion and resting energy expenditure in stressed patients. The metabolic effects of pentobarbital in sepsis were investigated in 29 well-nourished rats who underwent superior vena caval cannulation, cecal ligation, and puncture. Animals were randomly assigned to receive either a continuous infusion of 20 mg/kg/day of pentobarbital combined with parenteral nutrition (n = 13) or parenteral nutrition alone (n = 16). Both groups received isocaloric, isonitrogenous parenteral nutrition postoperatively for 24 hr. Mean nitrogen balance (±SEM) was better in the pentobarbital group (+169 ± 76 mg/kg/day us -190 ± 66 mg/kg/day, p < 0.01). No significant differences between the pentobarbital and control groups were noted for urinary 3-methylhistidine excretion (9 ± 0.7 µg/kg/day us 11 ± 0.6 µg/kg/day, respectively) or 24 hr survival (77% vs 69%, respectively). Pentobarbital improves nitrogen retention without decreasing urinary 3-methylhistidine excretion in septic rats. (Journal of Parenteral and Enteral Nutrition 13: 359-361, 1989)

Journal of Parenteral and Enteral Nutrition, Vol. 13, No. 4, 359-361 (1989)
DOI: 10.1177/0148607189013004359
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Home page
 Nutr Clin PractHome page
B. Magnuson, J. Hatton, S. Williams, and T. Loan
Tolerance and Efficacy of Enteral Nutrition for Neurosurgical Patients in Pentobarbital Coma
Nutr Clin Pract, June 1, 1999; 14(3): 131 - 134.
[Abstract] [PDF]