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Journal of Parenteral and Enteral Nutrition
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Review: Neonatal Parenteral Nutrition with Medium-Chain Triglycerides: Rationale for Research

L.A.M. Lima, M.D.

Department of Child Health, University of Wales College of Medicine, Cardiff, United Kingdom and Department of Paediatrics, University of Brasilia, Brazil

With the advances in technology stable fat emulsions containing medium-chain triglycerides (MCT) became available. Intravenous MCT are readily utilizable energy source because they reach the liver rapidly and their medium-chain fatty acids (MCFA) are oxidized through carnitine-independent mechanisms. However the MCFA can also be deviated to alternative oxidation pathways which results in urinary excretion of metabolites. The metabolic effects of intravenous MCT containing fat emulsions are discussed and emphasis is given in the possible role of these fats in parenteral nutrition of preterm infants, who are carnitine depleted. Directions of future research are speculated. (Journal of Parenteral and Enteral Nutrition 13:312-317, 1989)

Journal of Parenteral and Enteral Nutrition, Vol. 13, No. 3, 312-317 (1989)
DOI: 10.1177/0148607189013003312
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