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Preliminary Studies of a Dicarboxylic Acid as an Energy Substrate in Man

Instituto di Clinica Medica and Instituto di Clinica Chirurgica-Centro C. N.R. per lo studio della Fisiopatologia dello Shock, Università Cattolica S. Cuore, Rome, Italy

R.M. Tacchino

Instituto di Clinica Medica and Instituto di Clinica Chirurgica-Centro C. N.R. per lo studio della Fisiopatologia dello Shock, Università Cattolica S. Cuore, Rome, Italy

A.V. Greco

Instituto di Clinica Medica and Instituto di Clinica Chirurgica-Centro C. N.R. per lo studio della Fisiopatologia dello Shock, Università Cattolica S. Cuore, Rome, Italy

E. Arcieri-Mastromattei

Instituto di Clinica Medica and Instituto di Clinica Chirurgica-Centro C. N.R. per lo studio della Fisiopatologia dello Shock, Università Cattolica S. Cuore, Rome, Italy

F. Marino

Instituto di Clinica Medica and Instituto di Clinica Chirurgica-Centro C. N.R. per lo studio della Fisiopatologia dello Shock, Università Cattolica S. Cuore, Rome, Italy

E. Finotti

Instituto di Clinica Medica and Instituto di Clinica Chirurgica-Centro C. N.R. per lo studio della Fisiopatologia dello Shock, Università Cattolica S. Cuore, Rome, Italy

E. Castagneto

Instituto di Clinica Medica and Instituto di Clinica Chirurgica-Centro C. N.R. per lo studio della Fisiopatologia dello Shock, Università Cattolica S. Cuore, Rome, Italy

Azelaic acid (Az), a straight saturated chain nine carbon dicarboxylic acid, was administered in saline form to six healthy male volunteers by iv route. Serum levels of Az and urinary amounts of both azelaic and pimelic (C7) acids were measured by an improved gas liquid chromatographic method. Stoichiometric analysis of Az metabolism was compared with that of glucose and palmitic acid. The respiratory quotient (RQ) as well as the ATP/CO ₂ ratio of Az were quite similar to that of palmitic acid. Therefore, Az oxidation is associated with a low cost of ATP synthesis in terms of carbon dioxide production. At the infusion rate used (7.5 g/hr) more than 50% of the administered dose was excreted in the urine. However, the remaining portion was cleared from the plasma in 200 min suggesting an uptake by body tissues which was also confirmed by indirect calorimetric analysis. (Journal of Parenteral and Enteral Nutrition 13:299-305, 1989)

Journal of Parenteral and Enteral Nutrition, Vol. 13, No. 3, 299-305 (1989)
DOI: 10.1177/0148607189013003299


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