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Intravenous Fat Emulsion (Intralipid) Delays Gastric Emptying, but Does Not Cause Gastroesophageal Reflux in Healthy Volunteers

Departments of Pediatrics, Medicine, and Nuclear Medicine, University of California, Los Angeles, California

Karl Anders Dahlstrom, M.D.

Departments of Pediatrics, Medicine, and Nuclear Medicine, University of California, Los Angeles, California

Jorge Vargas, M.D.

Departments of Pediatrics, Medicine, and Nuclear Medicine, University of California, Los Angeles, California

Randy Hawkins, M.D.

Departments of Pediatrics, Medicine, and Nuclear Medicine, University of California, Los Angeles, California

Matz Mogard, M.D.

Departments of Pediatrics, Medicine, and Nuclear Medicine, University of California, Los Angeles, California

Marvin E. Ament, M.D.

Departments of Pediatrics, Medicine, and Nuclear Medicine, University of California, Los Angeles, California

The impact of overnight intravenous lipid emulsion (ILE) infusion on upper gastrointestinal tract physiology was assessed in 10 healthy volunteers. No changes in lower esophageal sphincter pressure (before infusion: 28 ± 4 mm Hg; after infusion 20.5 ± 3; p:NS), plasma concentrations of gastrointestinal hormones (gastrin: preprandial before/after lipids: 14 ± 2.1/13 ± 1.4 pM; postprandial before/after lipids: 28 ± 2.7/30 ± 3.4 pM, CCK: preprandial before/after lipids: 69 ± 10/64 ± 10 pM; postprandial before/after lipids: 96 ± 11/95 ± 12 pM; neurotensin: levels less than 6 pM in all samples; somatostatin levels undetectable in all samples) nor on pathologic gastroesophageal reflux episodes (% of time of pH < 4, before/after lipids: 0.6 ± 0.4/0.15 ± 0.09), were found (p = NS). In contrast, technetium gastric emptying studies showed a significant delay when comparing pre- and postlipid infusion values (37 ± 4/54 ± 4%) (p < 0.005). The mechanism of this effect remains unexplained. (Journal of Parenteral and Enteral Nutrition 13:246-248, 1989)

Journal of Parenteral and Enteral Nutrition, Vol. 13, No. 3, 246-248 (1989)
DOI: 10.1177/0148607189013003246


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