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Journal of Parenteral and Enteral Nutrition
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Serotonin Receptors in the Brain following Total Hepatectomy in Rats Treated with Branched-Chain Amino Acids

M. Bugge

Department of Surgery, University of Lund, Sweden

F. Bengtsson

Department of Surgery, University of Lund, Sweden

H. Hall

Department of Biochemical Neuropharmacology, Research and Development Laboratories, Södertälje, Sweden

I. Wedel

Department of Biochemical Neuropharmacology, Research and Development Laboratories, Södertälje, Sweden

A. Nobin

Department of Surgery, University of Lund, Sweden

B. Jeppsson

Department of Surgery, University of Lund, Sweden

P. Herlin

Department of Surgery, University of Lund, Sweden

Serotonin concentrations and receptor binding characteristics were investigated in rats subjected to total hepatectomy, portacaval shunt (PCS) or sham-operation. The animals were infused for 5 hr with a 10% glucose solution or the same solution enriched with 0.24 M branched-chain amino acids (BCAA). Hepatectomized animals were in grade-two coma at the end of the experiment independent of infusion. Indoleamines in mesencephalon-pons and diencephalon were analyzed by high-pressure liquid chromatography with electrochemical detection. Serotonin receptors (5-HT1 and 5-HT2) were investigated in the cortex and hippocampus by radioligand binding studies using 3H-serotonin for analysis. of 5-HT1receptors and 3H-ketanserin for analysis of 5-HT2-receptors. Concentrations of serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) were significantly increased after hepatectomy compared with controls. Treatment with BCAA significantly decreased 5-HT and 5-HIAA levels in hepatectomized animals. The affinity and the number of binding sites for the 5-HT1 and 5-HT2 receptors were found to be similar in all groups. The present study indicates that PCS for 1 week and the anhepatic state for 5 hr in rats do not influence brain serotonin receptors in contrast to previous studies in pigs with liver ischemia or rabbits with galactosamine-induced liver damage. In addition, infusion of BCAA for 5 hr did not alter the binding characteristics. ( Journal of Parenteral and Enteral Nutrition 13:235-239, 1989)

Journal of Parenteral and Enteral Nutrition, Vol. 13, No. 3, 235-239 (1989)
DOI: 10.1177/0148607189013003235
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Home page
 Nutr Clin PractHome page
G. L. Schmidt and P. Tan
Protein Supplementation in a Hepatic Resection Patient
Nutr Clin Pract, December 1, 1990; 5(6): 251 - 253.
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