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Pulmonary Deposition of Calcium Phosphate Crystals as a Complication of Home Total Parenteral Nutrition

Nutrition Support Service and Clinical Nutrition Research Unit, Department of Medicine, University of Chicago, Chicago, Illinois

Gil Cusson, B.S., R.PH.

Nutrition Support Service and Clinical Nutrition Research Unit, Department of Medicine, University of Chicago, Chicago, Illinois

Marilyn Smith, R.N.

Nutrition Support Service and Clinical Nutrition Research Unit, Department of Medicine, University of Chicago, Chicago, Illinois

Michael D. Sitrin, M.D.

Nutrition Support Service and Clinical Nutrition Research Unit, Department of Medicine, University of Chicago, Chicago, Illinois

A patient on home total parenteral nutrition (TPN) developed a diffuse granulomatous interstitial pneumonitis secondary to calcium phosphate deposition. Calcium and phosphorus concentrations in the TPN formula were not unusually high, indicating that other factors contributed to calcium phosphate crystallization. The effects of duration of storage of the TPN formulation, solution temperature, pH, and magnesium concentration on calcium phosphate precipitation are discussed. (Journal of Parenteral and Enteral Nutrition 13:209-213, 1989)

Journal of Parenteral and Enteral Nutrition, Vol. 13, No. 2, 209-213 (1989)
DOI: 10.1177/0148607189013002209


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