This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Souba, W. W. Articles by Rowlands, B. J. Search for Related Content PubMed PubMed Citation Articles by Souba, W. W. Articles by Rowlands, B. J. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB GLUCOSE Social Bookmarking                         What's this?

Effects of Enterectomy on Postoperative Visceral Organ Glucose Exchange

Departments of Surgery and Biochemistry, The University of Florida College of Medicine, Gainesville, Florida, Department of Surgery, The University of Texas Medical School, Houston, Texas

Patrick T. Roughneen, M.B., CH.B.

Departments of Surgery and Biochemistry, The University of Florida College of Medicine, Gainesville, Florida, Department of Surgery, The University of Texas Medical School, Houston, Texas

Diane L. Goldwater, M.D., PH.D.

Departments of Surgery and Biochemistry, The University of Florida College of Medicine, Gainesville, Florida, Department of Surgery, The University of Texas Medical School, Houston, Texas

R. Lawrence Reed, M.D.

Departments of Surgery and Biochemistry, The University of Florida College of Medicine, Gainesville, Florida, Department of Surgery, The University of Texas Medical School, Houston, Texas

Brian J. Rowlands, M.D., FRCS, FACS

Departments of Surgery and Biochemistry, The University of Florida College of Medicine, Gainesville, Florida, Department of Surgery, The University of Texas Medical School, Houston, Texas

The effects of a 60% small-bowel resection on postoperative visceral organ glucose exchange was studied in order to gain further understanding of the role of the intestinal tract as a supplier of gluconeogenic substrate to the liver following operative stress. We determined the flux of glucose across the gastrointestinal tract, liver, and kidneys in 20 postoperative dogs. With enterectomy portal bloodflow and total hepatic bloodflow were diminished by 33% and 25%, respectively. Arterial glucose was slightly lower in the enterectomized group 6 hr following the operation. Intestinal glucose uptake was diminished by more than 50% in the enterectomized dogs (p < 0.01). Net hepatic glucose release fell from 22 µmole/kg/ min to 8 µmole/kg/min (p < 0.01). In control animals the kidney was an organ of slight glucose uptake while in the enterectomized group, the kidney released glucose at the rate of 4.1 µmole/kg/min (p < 0.05). The data suggest that the gut is an important supplier of gluconeogenic precursors to the liver which are used to support gluconeogenesis in the postoperative period. The ability of the kidney to accelerate glucose production in this setting suggests that metabolic adaptation and cooperation between organs occurs during organ absence or dysfunction which helps preserve glucose homeostasis. (Journal of Parenteral and Enteral Nutrition 13:128-131, 1989)

Journal of Parenteral and Enteral Nutrition, Vol. 13, No. 2, 128-131 (1989)
DOI: 10.1177/0148607189013002128


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				D. F. Kirby, G. L. Clifton, H. Turner, D. W. Marion, J. Barrett, and H.-D. F. Gruemer Early Enteral Nutrition After Brain Injury by Percutaneous Endoscopic Gastrojejunostomy JPEN J Parenter Enteral Nutr, May 1, 1991; 15(3): 298 - 302. [Abstract] [PDF]