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Isotonic Tube Feeding Formula Induces Liquid Stool in Normal Subjects: Reversal by Pectina
Donna M. Zimmaro, R.N., M.S.N.
Departments of Nursing, Surgery and Otorhinolaryngology, University of Pennsylvania and the Veterans Medical Center, Department of Surgery, Graduate Hospital, Philadelphia, Pennsylvania, Department of Surgery, University of Medicine and Dentistry of New Jersey-School of Osteopathic Medicine, Camden, New Jersey
Rolando H. Rolandelli, M.D.
Departments of Nursing, Surgery and Otorhinolaryngology, University of Pennsylvania and the Veterans Medical Center, Department of Surgery, Graduate Hospital, Philadelphia, Pennsylvania, Department of Surgery, University of Medicine and Dentistry of New Jersey-School of Osteopathic Medicine, Camden, New Jersey
Mark J. Koruda, M.D.
Departments of Nursing, Surgery and Otorhinolaryngology, University of Pennsylvania and the Veterans Medical Center, Department of Surgery, Graduate Hospital, Philadelphia, Pennsylvania, Department of Surgery, University of Medicine and Dentistry of New Jersey-School of Osteopathic Medicine, Camden, New Jersey
R. Gregg Settle, PH.D.
Departments of Nursing, Surgery and Otorhinolaryngology, University of Pennsylvania and the Veterans Medical Center, Department of Surgery, Graduate Hospital, Philadelphia, Pennsylvania, Department of Surgery, University of Medicine and Dentistry of New Jersey-School of Osteopathic Medicine, Camden, New Jersey
T. Peter Stein, PH.D.
Departments of Nursing, Surgery and Otorhinolaryngology, University of Pennsylvania and the Veterans Medical Center, Department of Surgery, Graduate Hospital, Philadelphia, Pennsylvania, Department of Surgery, University of Medicine and Dentistry of New Jersey-School of Osteopathic Medicine, Camden, New Jersey
John L. Rombeau, M.D.
Departments of Nursing, Surgery and Otorhinolaryngology, University of Pennsylvania and the Veterans Medical Center, Department of Surgery, Graduate Hospital, Philadelphia, Pennsylvania, Department of Surgery, University of Medicine and Dentistry of New Jersey-School of Osteopathic Medicine, Camden, New Jersey
Diarrhea is one of the most common complications in patients who receive tube-feeding formulas. Since the colon is the final site of water and electrolyte absorption and ultimately determines fecal composition, diarrhea during tube feeding may result from altered colonic function. The lack of dietary fiber, such as pectin, in tube-feeding formulas may be one of the means by which colonic function is affected. The purpose of this study was to determine the effect of a standard, liquid, commercially available, isotonic tube-feeding formula (ITFF) and the effects of supplementing the ITFF with pectin on colonic function as measured by stool consistency and colonic fluid composition in 13 normal adults. Data were obtained when subjects consumed their regular diet, ITFF, and ITFF supplemented with pectin using the technique of in vivo dialysis of colonic fluid. Ingestion of the ITFF resulted in a significant increase in the percentage of liquid stools compared to a regular diet [median (interquartile range) = 0% (0), 60% (64);p < 0.01]. Ingestion of the ITFF also resulted in significant decreases in the concentrations of sodium, potassium, and short-chain fatty acids, and increases in pH and osmotic gap in colonic fluid compared to the subjects' regular diet. Supplementing the ITFF with pectin significantly reduced the incidence of liquid stools [0% (0)] and promoted a normalization of colonic fluid composition. The results suggest that the addition of pectin may enhance tolerance to ITFFs. (Journal of Parenteral and Enteral Nutrition (13:117-123, 1989)
Journal of Parenteral and Enteral Nutrition, Vol. 13, No. 2,
117-123 (1989)
DOI: 10.1177/0148607189013002117
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