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Journal of Parenteral and Enteral Nutrition
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Serotonin Metabolism in the Central Nervous System in Portacaval Shunted Rats Infused with Fat Emulsion

Finn Bengtsson, M.D., PH.D.

Department of Surgery, Lund University, Lund, Sweden

Mogens Bugge, M.D., PH.D.

Department of Surgery, Lund University, Lund, Sweden

Per Herlin, M.D., PH.D.

Department of Surgery, Lund University, Lund, Sweden

Anders Nobin, M.D., PH.D.

Department of Surgery, Lund University, Lund, Sweden

Bengt Jeppsson, M.D., PH.D.

Department of Surgery, Lund University, Lund, Sweden

Increased brain concentrations of tryptophan, and presumably thereby increased brain serotonin metabolism, have been observed following liver impairment and implicated in the etiology of portal-systemic encephalopathy (PSE). Increased plasma-free tryptophan (ie, not albumin-bound) concentrations can be expected after exogenous fat administration. This might further increase the brain serotonin metabolism in liver failure and negatively influence the PSE.

We treated rats 2 weeks after end-to-side portacaval shunt (PCS) with continous intravenous infusion of fat emulsion (Intralipid 20%) for 24 and 72 hr, respectively. The regional serotonin turnover was determined in different regions of the central nervous system (CNS) by measuring 5-hydroxyindole concentrations after NSD 1015 decarboxylase inhibition. The results revealed no further increase of the CNS serotonin turnover after fat infusion to PCS rats, compared with PCS rats given equal amounts of glucose. Thus, continuous infusion of a fat emulsion caused no major alteration of the CNS serotonin metabolism in PCS rats. (Journal of Parenteral and Enteral Nutrition 13:65-70, 1989)

Journal of Parenteral and Enteral Nutrition, Vol. 13, No. 1, 65-70 (1989)
DOI: 10.1177/014860718901300165
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