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Stability and Delivery of Vancomycin Hydrochloride When Admixed in a Total Parenteral Nutrition Solution

Department of Pharmacy, Minneapolis Childrens Medical Center, Department of Pharmacy Practice, University of Minnesota College of Pharmacy, and Medtox Laboratories, Inc., Minneapolis, MN 55404

David M. Watson, PHARM.D.

Department of Pharmacy, Minneapolis Childrens Medical Center, Department of Pharmacy Practice, University of Minnesota College of Pharmacy, and Medtox Laboratories, Inc., Minneapolis, MN 55404

Harry G. McCoy, PHARM.D.

Department of Pharmacy, Minneapolis Childrens Medical Center, Department of Pharmacy Practice, University of Minnesota College of Pharmacy, and Medtox Laboratories, Inc., Minneapolis, MN 55404

Donald L. Uden, PHARM.D.

Department of Pharmacy, Minneapolis Childrens Medical Center, Department of Pharmacy Practice, University of Minnesota College of Pharmacy, and Medtox Laboratories, Inc., Minneapolis, MN 55404

Vancomycin hydrochloride, 400 mg/liter was mixed in six standard pediatric parenteral nutrition solutions with and without heparin added. The solutions were stored over a period of 8 days (192 hr) under refrigeration and at room temperature. Aliquots from all six solutions were assayed in duplicate for vancomycin at time 0, 24, 96, and 192 hr. All samples were run through an Ivex 0.22-micron filter, observed for physical incompatibilities, and frozen at —70°C until assay.

Our results indicate that vancomycin was stable and was delivered with loss in concentration of less than 5% with and without storage under refrigeration.

This study suggests an alternative method for delivering vancomycin when treating a catheter-related infection. If vancomycin is delivered in this fashion, less manipulations of the line would be required. In addition, there may be a theoretical advantage of constantly bathing the catheter with vancomycin when the catheter is suspected of harboring the infecting organism. (Journal of Parenteral and Enteral Nutrition 13:63-64, 1989)

Journal of Parenteral and Enteral Nutrition, Vol. 13, No. 1, 63-64 (1989)
DOI: 10.1177/014860718901300163


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