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Journal of Parenteral and Enteral Nutrition
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Extraction of Diethylhexylphthalate from Total Nutrient Solution-Containing Polyvinyl Chloride Bags

Helen I. Mazur

Pharmacy-IV Department, Good Samaritan Hospital, Portland

Douglass J. Stennett

College of Pharmacy, Oregon State University, Corvallis, Oregon

Paulette K. Egging

Pharmacy-IV Department, Good Samaritan Hospital, Portland

Total nutrient solution (TNS) is a new method for delivering total parenteral nutrition (TPN) by admixing dextrose, amino acids, and lipids in a single container. Recommendations are to use nonpolyvinyl chloride (PVC) containers for admixture of these solutions. PVC is a hard, brittle, and inflexible substance, and plasticizers, predominantly diethylhexylphthalate (DEHP), are added to impart flexibility. DEHP is a lipid soluble suspected carcinogen, hepatotoxin, and teratogen which has been shown to leach from PVC products containing lipophilic admixtures. The purpose of this study was to quantitate the amount of DEHP which leaches from PVC bags containing TNS.

Six study groups, which contained three formulas stored at 25°C ± 2°C and 4°C ± 1°C, were assayed for DEHP at time 0, 12, 24, 48 and 72 hr, 1 wk, and 3 wk using high-performance liquid chromatography. The control group contained an amino acid source, a carbohydrate source, and standard electrolytes, and the other groups contained a 10% lipid source or a 20% lipid source in addition to the constituents of the control group.

Lipid-containing groups demonstrated detectable levels of DEHP at 48 hr, and DEHP content increased in these groups throughout the 21-day study. DEHP concentrations were lower in lipid-containing groups stored at 4°C than comparable groups stored at 25°C. (Journal of Parenteral and Enteral Nutrition 13:59-62, 1989)

Journal of Parenteral and Enteral Nutrition, Vol. 13, No. 1, 59-62 (1989)
DOI: 10.1177/014860718901300159
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[Abstract] [PDF]