This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Spielmann, D. Articles by Cotter, R. Search for Related Content PubMed PubMed Citation Articles by Spielmann, D. Articles by Cotter, R. Social Bookmarking                         What's this?

Alternative Lipids to Usual 6 PUFAS: -Linolenic Acid, -Linolenic Acid, Stearidonic Acid, EPA, Etc

Nestec Limited, Nestlé Research Centre, Lausanne, Switzerland

U. Bracco, PH.D.

Nestec Limited, Nestlé Research Centre, Lausanne, Switzerland

H. Traitler, PH.D.

Nestec Limited, Nestlé Research Centre, Lausanne, Switzerland

G. Crozier, PH.D.

Nestec Limited, Nestlé Research Centre, Lausanne, Switzerland

R. Holman, PH.D.

University of Minnesota, Hormel Institute, Austin, MN

M. Ward, D.V.M.

Clintec Nutrition, Deerfield, Illinois

R. Cotter, PH.D.

Clintec Nutrition, Deerfield, Illinois

The intravenous administration of parenteral fat emulsions is widely used in total parenteral nutrition (TPN) to supply essential fatty acids and concentrated energy in a relatively small volume of isotonic solution. They contain very high amounts of linoleic acid and usually about 8% of -linolenic acid calculated in the fat phase (10 or 20% of the total emulsion). Most of the time one emulsion is given as the sole source of fat, giving direct venous entry to a fatty acid composition substantially different from that encountered in a normal diet.

Since the latter greatly influences the fatty acid composition of phospholipids which are critical determinants of membrane structural properties influencing a variety of membrane functions (Fig. 1) (enzyme activity, membrane transport, receptor function) and functional precursors of intracellular and intercellular mediators (diacylglycerols, prostaglandins, leukotrienes, hydroxy fatty acids), do we provide the right fatty acid at the right place and the right time for efficient cell cell interaction? In other words, given the three roles of fatty acids—energetic, structural, functional—are we using the best strategy to avoid imbalances between the three roles? (Journal of Parenteral and Enteral Nutrition 12:111S-123S, 1988)

Journal of Parenteral and Enteral Nutrition, Vol. 12, No. 6 Suppl, 111S-123S (1988)
DOI: 10.1177/014860718801200618


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				B. A. Mizock and S. J. DeMichele The Acute Respiratory Distress Syndrome: Role of Nutritional Modulation of Inflammation Through Dietary Lipids Nutr Clin Pract, December 1, 2004; 19(6): 563 - 574. [Abstract] [Full Text] [PDF]

				B. A. Mizock Nutritional Support in Acute Lung Injury and Acute Respiratory Distress Syndrome Nutr Clin Pract, December 1, 2001; 16(6): 319 - 328. [Abstract] [PDF]

				R. Abushufa, P. Reed, C. Weinkove, S. Wales, and J. Shaffer Essential Fatty Acid Status in Patients on Long-Term Home Parenteral Nutrition JPEN J Parenter Enteral Nutr, July 1, 1995; 19(4): 286 - 290. [Abstract] [PDF]