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Journal of Parenteral and Enteral Nutrition
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Clinical Studies on a Newly Deviced Amino Acid Solution for Neonates

Kenji Imura

Department of Pediatric Surgery, Osaka University Medical School and Osaka Medical Center for Maternal and Child Health, Osaka, Japan

Akira Okada

Department of Pediatric Surgery, Osaka University Medical School and Osaka Medical Center for Maternal and Child Health, Osaka, Japan

Yuichi Fukui

Department of Pediatric Surgery, Osaka University Medical School and Osaka Medical Center for Maternal and Child Health, Osaka, Japan

Hisayoshi Kawahara

Department of Pediatric Surgery, Osaka University Medical School and Osaka Medical Center for Maternal and Child Health, Osaka, Japan

Makoto Yagi

Department of Pediatric Surgery, Osaka University Medical School and Osaka Medical Center for Maternal and Child Health, Osaka, Japan

Akio Kubota

Department of Pediatric Surgery, Osaka University Medical School and Osaka Medical Center for Maternal and Child Health, Osaka, Japan

Shinobu Kanaya

Department of Pediatric Surgery, Osaka University Medical School and Osaka Medical Center for Maternal and Child Health, Osaka, Japan

Shinkichi Kamata

Department of Pediatric Surgery, Osaka University Medical School and Osaka Medical Center for Maternal and Child Health, Osaka, Japan

Yoshio Nagata

Department of Pediatric Surgery, Osaka University Medical School and Osaka Medical Center for Maternal and Child Health, Osaka, Japan

In 97 neonates receiving total parenteral nutrition in the postoperative period, clinical assessment was made for a newly devised amino acid solution (PF-I-III) from the standpoint of plasma amino acid profile and nutritional effect. These amino acid solutions prepared are characterized by the high concentration of branched-chain amino acids up to 40%, increased arginine and decreased glycine, phenylalanine and methionine as compared with commercially available solutions. In the PF group, each amino acid was kept within the range of standard value. Correlation between plasma amino acid profiles and the dose of each amino acid administered was obtained, from which minimum, standard, and maximum doses for each amino acid was determined. Based on these values, we proposed new formula for neonates which elicits no abnormal plasma amino acid pattern even when amino acids are administered at the dosage level of 1.5-2.5 g/kg/day. (Journal of Parenteral and Enteral Nutrition 12:496-504, 1988)

Journal of Parenteral and Enteral Nutrition, Vol. 12, No. 5, 496-504 (1988)
DOI: 10.1177/0148607188012005496
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