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Journal of Parenteral and Enteral Nutrition
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Plasma Carotenoid Profiles in Normals and Patients with Cancer

Michael M. Meguid, M.D., PH.D., F.A.C.S.

Departments of Clinical Nutrition, and General and Oncologic Surgery, City of Hope National Medical Center, Duarte, California

Aurora M. Landel, PH.D.

Departments of Clinical Nutrition, and General and Oncologic Surgery, City of Hope National Medical Center, Duarte, California

Lily Oey, B.S.

Departments of Clinical Nutrition, and General and Oncologic Surgery, City of Hope National Medical Center, Duarte, California

Donald S. Mclaren, M.D., PH.D., F.R.C.P

Reader in Clinical Nutrition, Department of Medicine, Edinburgh University, Edinburgh EH 3 9 YW, Scotland, United Kingdom

Most human cancers arise in epithelial tissues, which are critically dependent on vitamin A for normal differentiation and proliferation. Dietary carotenoids consist of individual retinoids—pro-vitamin A precursors and non-pro-vitamin A precursors—displaying different biological activity. Although epidemiological data suggest that low serum vitamin A levels were associated with an increased risk of cancer, it is not known whether one specific or all vitamin A carotenoids are involved.

To assess whether the plasma carotenoids are related to the nutritional or cancer-bearing state, a study was conducted to measure total and individual carotenoids in four groups: cancer-bearing, malnourished; cancer-bearing, well-nourished; non-cancer, malnourished; and well-nourished volunteers of comparable age and sex.

There was no difference in total carotenoids and pro-vitamin A precursors between the well—nourished—both normal volunteers and cancer patients. Malnourished cancer and non-cancer patients had significantly (p < 0.05) lower value of both. Most of the circulating carotenoids in all groups were the non-pro-vitamin A precursors. Both malnourished cancer and non-cancer patients had lower values than well-nourished (p < 0.05). Differences were related to nutritional state, rather than presence of cancer. (Journal of Parenteral and Enteral Nutrition 12:147-151, 1988)

Journal of Parenteral and Enteral Nutrition, Vol. 12, No. 2, 147-151 (1988)
DOI: 10.1177/0148607188012002147
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