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Journal of Parenteral and Enteral Nutrition
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Case Reports

Successful Treatment of Superior Vena Cava Syndrome with Urokinase in an Infant

Claire M. Wilson, M.D.

Division of Digestive Disease and Nutrition, Childrens Hospital of Los Angeles, University of Southern California School of Medicine, Los Angeles, California

Russell J. Merritt, M.D., PH.D.

Division of Digestive Disease and Nutrition, Childrens Hospital of Los Angeles, University of Southern California School of Medicine, Los Angeles, California

Daniel W. Thomas, M.D.

Division of Digestive Disease and Nutrition, Childrens Hospital of Los Angeles, University of Southern California School of Medicine, Los Angeles, California

An 11-month-old infant with a central venous catheter for total parenteral nutrition for short gut syndrome developed head and neck swelling. A thrombus at the catheter tip occluding the superior vena cava was demonstrated roentgenographically. A 48-hr infusion of urokinase (4400 units/kg/ hr) was administered for thrombolysis. The thrombus cleared clinically and roentgenographically without adverse effects. There has been no recurrence of the superior vena cava syndrome. Urokinase infusion is an alternative to immediate catheter removal in selected patients. (Journal of Parenteral and Enteral Nutrition 12:81-83, 1988)

Journal of Parenteral and Enteral Nutrition, Vol. 12, No. 1, 81-83 (1988)
DOI: 10.1177/014860718801200181
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