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Effect of Nucleotide Restriction and Supplementation on Resistance to Experimental Murine Candidiasis

Department of Biochemistry, Rice University

Anil D. Kulkarni, M.S.

Department of Surgery, Division of Immunology and Organ Transplantation, The University of Texas Medical School, Houston, Texas

Charles T. Van Buren, M.D.

Department of Surgery, Division of Immunology and Organ Transplantation, The University of Texas Medical School, Houston, Texas

Frederick B. Rudolph, PH.D.

The influence of dietary nucleotides on susceptibility to candidiasis in mice was studied using two criteria: animal survival and recovery of viable Candida albicans organisms from the kidney and spleen. One-month-old mice were placed on one of five diets with varying nucleotide content. The results show that mice maintained on a nucleotide-free diet (NF) exhibit a significantly decreased mean survival time and a significantly increased viable organism recovery in the spleen following intravenous injection of graded inocula of C. albicans compared to mice fed diets containing RNA or uracil as a nucleotide source. (Journal of Parenteral and Enteral Nutrition 12:49-52, 1988)

Journal of Parenteral and Enteral Nutrition, Vol. 12, No. 1, 49-52 (1988)
DOI: 10.1177/014860718801200149


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