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Total Parental Nutrition Using Conventional and Medium Chain Triglycerides: Effect on Liver Function Tests, Complement, and Nitrogen Balance

Nuffield Department of Surgery, John Radcliffe Hospital, Headington, Oxford 0X3 9DU England

M. Ball, M.R.C.P.

Department of Clinical Biochemistry, John Radcliffe Hospital, Headington, Oxford 0X3 9DU England

L.J. Hands, F.R.C.S.

Nuffield Department of Surgery, John Radcliffe Hospital, Headington, Oxford 0X3 9DU England

P.J. Crowe, M.B., B.S.

Nuffield Department of Surgery, John Radcliffe Hospital, Headington, Oxford 0X3 9DU England

R.M. Watkins, F.R.C.S.

Nuffield Department of Surgery, John Radcliffe Hospital, Headington, Oxford 0X3 9DU England

M. Kettlewell, M.S., F.R.C.S.

Nuffield Department of Surgery, John Radcliffe Hospital, Headington, Oxford 0X3 9DU England

Conventional long chain triglyceride (LCT) was compared with a new emulsion containing 50% medium chain triglyceride (5% MCT/5% LCT) in a randomized cross-over trial of 10 days duration. Plasma concentrations of albumin, prealbumin, the complement components C3 and C4, and pro-thrombin times measured daily at 8 am, before lipid infusion, showed no progressive change during the 10 days of the trial, nor in each separate 5-day period when LCT or MCT/LCT was infused. Aspartate transaminase and alkaline phosphatase activities were similar over the two periods. There was a significant increase (compared with preinfusion levels) in C3 and C4 levels after 5 hr of either lipid infusion. Nitrogen balance was improved, and plasma bilirubin levels were lower on the regimen containing MCT/LCT. (Journal of Parenteral and Enteral Nutrition 12:15-19, 1988)

Journal of Parenteral and Enteral Nutrition, Vol. 12, No. 1, 15-19 (1988)
DOI: 10.1177/014860718801200115


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