This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Trocki, O. Articles by Alexander, J. W. Search for Related Content PubMed PubMed Citation Articles by Trocki, O. Articles by Alexander, J. W. Social Bookmarking                         What's this?

Effects of Fish Oil on Postburn Metabolism and Immunity

Shriners Burns Institute, Cincinnati, Ohio

Timothy J. Heyd, B.S.

Shriners Burns Institute, Cincinnati, Ohio

J. Paul Waymack, M.D.

Shriners Burns Institute, Cincinnati, Ohio

J. Wesley Alexander, M.D., Sc.D.

Shriners Burns Institute, Cincinnati, Ohio

The metabolic effects and immune responses of different levels of fish oil in enteral formulas for postburn nutritional support were studied. Thirty-seven burned guinea pigs with previously placed gastrostomy feeding tubes were given diets containing 5, 15, 30, or 50% of nonprotein calories as fish oil. These diets were isonitrogenous, isocaloric, and contained identical amounts of vitamins and minerals. After 14 days of enteral feeding, there were no significant differences in resting metabolic expenditure, serum transferrin, and albumin levels. Weight loss was significantly greater in groups receiving 30 and 50% of fish oil compared to groups which received 5 and 15% of fish oil. Carcass weights and liver weights of animals in the two groups that received diets with higher lipid content were also significantly lower. Cell-mediated immunity, macrophage bactericidal indices, and opsonic indices were not different among the groups. This study confirms that diets containing lower levels of lipids are more effective for enteral nutritional support than those containing higher levels. In contrast to linoleic acid rich lipid sources, higher levels of fish oil did not show adverse effects on immunity possibly because it contained high concentrations of 3 fatty acids which are not precursors of immunosuppressive prostaglandin E₂. (Journal of Parenteral and Enteral Nutrition 11:521-528, 1987)

Journal of Parenteral and Enteral Nutrition, Vol. 11, No. 6, 521-528 (1987)
DOI: 10.1177/0148607187011006521


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				M. Senkal, B. Geier, M. Hannemann, T. Deska, J. Linseisen, G. Wolfram, and M. Adolph Supplementation of {Omega}-3 Fatty Acids in Parenteral Nutrition Beneficially Alters Phospholipid Fatty Acid Pattern JPEN J Parenter Enteral Nutr, January 1, 2007; 31(1): 12 - 17. [Abstract] [Full Text] [PDF]

				M. Senkal, R. Haaker, J. Linseisen, G. Wolfram, H.-H. Homann, and P. Stehle Preoperative Oral Supplementation with Long-Chain {Omega}-3 Fatty Acids Beneficially Alters Phospholipid Fatty Acid Patterns in Liver, Gut Mucosa, and Tumor Tissue JPEN J Parenter Enteral Nutr, July 1, 2005; 29(4): 236 - 240. [Abstract] [Full Text] [PDF]

				D. R. Garrel, M. Razi, F. Lariviere, N. Jobin, N. Naman, A. Emptoz-Bonneton, and M. M. Pugeat Improved Clinical Status and Length of Care With Low-Fat Nutrition Support in Burn Patients JPEN J Parenter Enteral Nutr, November 1, 1995; 19(6): 482 - 491. [Abstract] [PDF]

				R. G. Barton Invited Review: Nutrition Support in Critical Illness Nutr Clin Pract, August 1, 1994; 9(4): 127 - 139. [Abstract] [PDF]

				L. E. Matarese Rationale and Efficacy of Specialized Enteral Nutrition Nutr Clin Pract, April 1, 1994; 9(2): 58 - 64. [Abstract] [PDF]

				C. J. Gollaher, K. Fechner, M. Karlstad, V. K. Babayan, and B. R. Bistrian The Effect of Increasing Levels of Fish Oil-Containing Structured Triglycerides on Protein Metabolism in Parenterally Fed Rats Stressed by Burn Plus Endotoxin JPEN J Parenter Enteral Nutr, May 1, 1993; 17(3): 247 - 253. [Abstract] [PDF]

				M. M. Gottschlich Invited Review: Selection of Optimal Lipid Sources in Enteral and Parenteral Nutrition Nutr Clin Pract, August 1, 1992; 7(4): 152 - 165. [Abstract] [PDF]

				W. H. Hartl and R. R. Wolfe Review: The Phospholipid/Arachidonic Acid Second Messenger System: Its Possible Role in Physiology and Pathophysiology of Metabolism JPEN J Parenter Enteral Nutr, July 1, 1990; 14(4): 416 - 427. [Abstract] [PDF]

				M. M. Gottschlich, M. Jenkins, G. D. Warden, T. Baumer, P. Havens, J. T. Snook, and J. W. Alexander Differential Effects of Three Enteral Dietary Regimens on Selected Outcome Variables in Burn Patients JPEN J Parenter Enteral Nutr, May 1, 1990; 14(3): 225 - 236. [Abstract] [PDF]

				G. L. Blackburn In Search of the "Preferred Fuel" Nutr Clin Pract, February 1, 1989; 4(1): 3 - 5. [PDF]