This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Acosta, P. B. Articles by Koch, R. Search for Related Content PubMed PubMed Citation Articles by Acosta, P. B. Articles by Koch, R. Social Bookmarking                         What's this?

Trace Element Status of PKU Children Ingesting an Elemental Diet

Department of Nutrition and Food Science, Florida State University, Tallahassee, Florida

Sareen Stepnick-Gropper, M.S.

Department of Nutrition and Food Science, Florida State University, Tallahassee, Florida

Noreen Clarke-Sheehan., R.N.

Children's Hospital of Los Angeles, Los Angeles, California

Elizabeth Wenz, M.S.

Children's Hospital of Los Angeles, Los Angeles, California

Mary Cheng, PH.D.

Children's Hospital of Los Angeles, Los Angeles, California

Kathryn Anderson, PH.D.

Department of Nutrition and Food Science, Florida State University, Tallahassee, Florida

Richard Koch, M.D.

Children's Hospital of Los Angeles, Los Angeles, California

We assessed the trace metal status of 10 children (3.5 to 13.3 yr) with phenylketonuria (PKU) who were successively treated for at least 6 months with a semi-synthetic formula restricted in phenylalanine, then for 6 months with a reformulated formula. The reformulated product contained higher concentrations of magnesium (Mg), potassium (K), phosphorus (P), selenium (Se), and zinc (Zn) and lower concentrations of calcium (Ca), sodium (Na), and unsaturated fats. Diet records, blood samples, and urine specimens were collected from each subject. Mean intakes of Mg, K, and Zn increased significantly when subjects were switched to the reformulated product. The subject's mean intakes of Se (for all age groups) and Zn (children 11 to 14 yr old) were below 67% of recommended intakes while they were ingesting the original formula. The mean trace metal concentrations of urine, blood, and serum did not differ significantly during the two periods. Mean serum Zn, Se, and Cu concentrations of the subjects were less than those reported for normal children. Significant negative correlations were obtained between serum Zn concentrations and the molar ratio of dietary (Ca + P):Zn, and the molar ratio of dietary Fe:Zn. No significant differences in mean urinary Cu and Zn excretion (mg/g creatinine) were observed in subjects after they were changed to the reformulated product. Individuals whose primary source of energy and protein is derived from semi-synthetic elemental diets are especially at risk for multiple trace element deficiencies. (Journal of Parenteral and Enteral Nutrition 11:287-292, 1987)

Journal of Parenteral and Enteral Nutrition, Vol. 11, No. 3, 287-292 (1987)
DOI: 10.1177/0148607187011003287


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				A. C. Muntau, M. Streiter, M. Kappler, W. Roschinger, I. Schmid, A. Rehnert, P. Schramel, and A. A. Roscher Age-related Reference Values for Serum Selenium Concentrations in Infants and Children Clin. Chem., March 1, 2002; 48(3): 555 - 560. [Abstract] [Full Text] [PDF]

				M. M. van Bakel, G. Printzen, B. Wermuth, and U. N Wiesmann Antioxidant and thyroid hormone status in selenium-deficient phenylketonuric and hyperphenylalaninemic patients Am. J. Clinical Nutrition, October 1, 2000; 72(4): 976 - 981. [Abstract] [Full Text] [PDF]

				S. S. Gropper and P. B. Acosta Effect of Simultaneous Ingestion of L-Amino Acids and Whole Protein on Plasma Amino Acid and Urea Nitrogen Concentrations in Humans JPEN J Parenter Enteral Nutr, January 1, 1991; 15(1): 48 - 53. [Abstract] [PDF]