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Journal of Parenteral and Enteral Nutrition
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Clinical Trial

Double-Blind Study of Glycerol vs Glucose in Parenteral Nutrition of Postsurgical Insulin-Treated Diabetic Patients

A. Lev-Ran, M.D.

City of Hope National Medical Center, Duarte, California

M. Johnson, M.D

t City of Hope National Medical Center, Duarte, California

D.L. Hwang, PH.D.

t City of Hope National Medical Center, Duarte, California

J. Askanazi, M.D.

Columbia Uniuersity, New York, New York

C. Weissman, M.D.

Columbia Uniuersity, New York, New York

M. Gersovitz, PH.D.

Kendall-McGaw Laboratories, Irvine, California

Twenty-five insulin-treated diabetic patients were randomly assigned postoperatively to 5 days of intravenous infusions of ProcalAmine (3% amino acids, 3% glycerol, and electrolytes) or FreAmineIII + dextrose and electrolytes. The solutions were given isocalorically and isonitrogenously. Insulin was adjusted to keep glycemia at the level of 150-200 mg/dl. The ProcalAmine group by the 5th day had plasma glucose of 158 ± 25 mg/dl and required 1.20 ± 0.10 U/hr insulin. The FreAmine + dextrose group had plasma glucose of 169 ± 53 mg/dl and required 2.28 ± 0.13 U/hr. At all time points postsurgically, the ProcalAmine group required less insulin. (Journal of Parenteral and Enteral Nutrition 11:274-274, 1987)

Journal of Parenteral and Enteral Nutrition, Vol. 11, No. 3, 271-274 (1987)
DOI: 10.1177/0148607187011003271
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Home page
 JPEN J Parenter Enteral NutrHome page
K. Waxman, A. T. Day, G. P. Stellin, G. T. Tominaga, A. B. Gazzaniga, and R. R. Bradford
Safety and Efficacy of Glycerol and Amino Acids in Combination With Lipid Emulsion for Peripheral Parenteral Nutrition Support
JPEN J Parenter Enteral Nutr, July 1, 1992; 16(4): 374 - 378.
[Abstract] [PDF]