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Relationship of Antioxidant Enzymes to Trace Metals in Premature Infants

Division of Neonatology, Department of Pediatrics, Emanuel Hospital, The Department of Biochemistry, School of Dentistry, Oregon Health Sciences University, Department of Pediatrics, Oregon Health Sciences University, Portland, Oregon

Thomas R. Shearer, PH.D.

Division of Neonatology, Department of Pediatrics, Emanuel Hospital, The Department of Biochemistry, School of Dentistry, Oregon Health Sciences University, Department of Pediatrics, Oregon Health Sciences University, Portland, Oregon

Barbara J. Jelen, B.A.

Division of Neonatology, Department of Pediatrics, Emanuel Hospital, The Department of Biochemistry, School of Dentistry, Oregon Health Sciences University, Department of Pediatrics, Oregon Health Sciences University, Portland, Oregon

P. Danielle Whall, B.S.N., N.N.C.

Division of Neonatology, Department of Pediatrics, Emanuel Hospital, The Department of Biochemistry, School of Dentistry, Oregon Health Sciences University, Department of Pediatrics, Oregon Health Sciences University, Portland, Oregon

John W. Reynolds, M.D.

Division of Neonatology, Department of Pediatrics, Emanuel Hospital, The Department of Biochemistry, School of Dentistry, Oregon Health Sciences University, Department of Pediatrics, Oregon Health Sciences University, Portland, Oregon

Serum levels of the trace metals copper, zinc, and selenium were measured in premature infants. White blood cell glutathione peroxidase and superoxide dismutase levels were measured in conjunction with the trace metals. Three groups of infants were evaluated: group I was relatively healthy, group II were infants with stage 2 bronchopulmonary dysplasia (BPD) or less, group III were infants with stage 3 BPD or worse. Zinc and selenium levels declined in all groups during conventional parenteral nutrition (TPN) regimens, while copper remained stable. Copper did decline in groups I and II coincident with an acceleration in growth rate. An expected rise in antioxidant enzyme levels in infants with pulmonary oxygen toxicity was not seen. This study suggests that supplemental selenium as well as an increased zinc intake over current recommendations for premature infants receiving TPN may be indicated. (Journal of Parenteral and Enteral Nutrition 11: 163-168, 1987)

Journal of Parenteral and Enteral Nutrition, Vol. 11, No. 2, 163-168 (1987)
DOI: 10.1177/0148607187011002163


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