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Journal of Parenteral and Enteral Nutrition
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Clinical Trial

A Comparison of Two 20% Lipid Emulsions

Karl Anders Dahlstrom, M.D., PH.D.

Department of Pediatrics, UCLA School of Medicine, Los Angeles, California, Alpha Therapeutic Corporation, Los Angeles, California

Norma Mcintosh, PH.D., R.D.

Department of Pediatrics, UCLA School of Medicine, Los Angeles, California, Alpha Therapeutic Corporation, Los Angeles, California

Marvin Earl Ament, M.D.

Department of Pediatrics, UCLA School of Medicine, Los Angeles, California, Alpha Therapeutic Corporation, Los Angeles, California

Two different soy oil emulsions (Intralipid and Soyacal) were studied over a 2-week period in a random crossover study to determine if there were clinical or biochemical differences between the two preparations when used in patients requiring total parenteral nutrition (TPN). Each fat emulsion was infused randomly over 1 week and then switched to the other. Eighteen adult patients requiring a minimum of 14 days TPN were studied. None of the 26 metabolic parameters evaluated was statistically different between the two groups. Analysis of nutritional status, irrespective of lipid infused, showed that the patients who received 56 kcal/kg/day with 37% of the nonprotein calories from lipids (1.8 ± 0.7 g/kcal/day) were in positive nitrogen balance on 80 of the 101 days studied. No adverse effects could be observed from either lipid emulsion during the short period of TPN used in this study. Both lipid emulsions were efficacious as a caloric source, and no clinical complications or biochemical abnormalities were found from either preparation. (Journal of Parenteral and Enteral Nutrition 11:149-151, 1987)

Journal of Parenteral and Enteral Nutrition, Vol. 11, No. 2, 149-151 (1987)
DOI: 10.1177/0148607187011002149
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