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Mild Peripheral Neuropathy but Biochemical Chromium Sufficiency during 16 Months of "Chromium-Free" Total Parenteral Nutrition

Section of Clinical Nutrition, Department of Medicine and the Departments of Pediatrics and Biochemistry, West Virginia University School of Medicine, Morgantown, West Virginia

C. Veillon, PH.D.

Human Nutrition Research Center, U.S.D.A., Beltsville, Maryland

K.Y. Patterson, M.S.

Human Nutrition Research Center, U.S.D.A., Beltsville, Maryland

P.M. Farrell, M.D., PH.D.

Department of Pediatrics, School of Medicine, University of Wisconsin, Madison

A 6-yr, 4-month-old boy was started on total parenteral nutrition (TPN) because of chronic diarrhea. The TPN regimen (3 liter/day) initially included supplemented Cr (3 µg/day) in addition to standard components (including FreAmine III). At age 8 yr, 8 months, the serum Cr level was elevated: 3.7 ng/ml (normal 0.03-0.85). A repeat level at the same time by another commercial laboratory was also high (7.0). Cr supplementation was stopped. At age 10 yr, he was noted to have mild peripheral neuropathy although glucose tolerance was excellent (-linolenic acid was undetectable in the plasma). Cr status was reevaluated in a research lab. The serum level was 1.4 ng/ml (normal 0.05-0.4). The urine chromium excretion was 1.27 µg/day (normal 0.22). The TPN regimen (unsupplemented with Cr) provided 4 µg/day. Normal Cr intake is about 60 µg/day with 0.4% absorption (net 0.24 µg/day). We conclude that Cr contamination of standard PN fluid may prevent biochemical evidence of low Cr status. In addition, -linolenic acid-free parenteral nutrition for 46 months was not associated with clinically significant neurological dysfunction. (Journal of Parenteral and Enteral Nutrition 10:662-664, 1986)

Journal of Parenteral and Enteral Nutrition, Vol. 10, No. 6, 662-664 (1986)
DOI: 10.1177/0148607186010006662


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