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Journal of Parenteral and Enteral Nutrition
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Influence of Parenteral Nutrition on Phospholipid Metabolism in Posttraumatic Rat Lungs

Soheyl Bahrami, PH.D.

Ludwig Boltzmann Institute for Experimental Traumatology, Vienna, Austria

Harald Gasser

Ludwig Boltzmann Institute for Experimental Traumatology, Vienna, Austria

Heinz Redl, PH.D.

Ludwig Boltzmann Institute for Experimental Traumatology, Vienna, Austria

Wolfgang Strohmaier, PH.D.

Ludwig Boltzmann Institute for Experimental Traumatology, Vienna, Austria

Guenther Schlag, M.D.

Ludwig Boltzmann Institute for Experimental Traumatology, Vienna, Austria

In the current investigation, we studied two groups of rats—one group supplied exogenous phospholipid precursors (carbohydrate plus fat emulsion group) and the other given only calories (carbohydrate group)—to evaluate the effects on surfactant composition by normocaloric alimentation, using a hypovolemic-traumatic shock model. The total phospholipid (PHL) contents of lung tissue were similar in both groups. However, we found differences in the dipalmitoylphosphatidylcholine fraction (DPPC—the most important component of surfactant material) in both lung tissue and lavage fluid. With lipid emulsion, there was an increased fraction of saturated lecithins (mainly DPPC) both in lung tissue and lavage fluid, similar to former studies with hypocaloric alimentation. In this model, those findings suggest that the PHL pattern does not depend on the quantity of caloric supply, but, rather, on the infusion composition. The enhanced DPPC content is further reflected in improved surfactant status: lipid in parenteral nutrition (PN) may exert a direct salutary effect on lung mechanics. (Journal of Parenteral and Enteral Nutrition 10:617-621, 1986)

Journal of Parenteral and Enteral Nutrition, Vol. 10, No. 6, 617-621 (1986)
DOI: 10.1177/0148607186010006617
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Home page
 JPEN J Parenter Enteral NutrHome page
S. Bahrami, W. Strohmaier, H. Redl, and G. Schlag
Mechanical Properties of the Lungs of Posttraumatic Rats Are Improved by Including Fat in Total Parenteral Nutrition
JPEN J Parenter Enteral Nutr, November 1, 1987; 11(6): 560 - 565.
[Abstract] [PDF]