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Journal of Parenteral and Enteral Nutrition
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Postoperative Parenteral Nutrition with High Supply of Branched-Chain Amino Acids: Effects on Nitrogen Balance and Liver Protein Synthesis

Olli Kirvelä, M.D.

Department of Anaesthesiology, Turku University Central Hospital, 20520 Turku, Finland

Jukka Takala, M.D.

Department of Anaesthesiology, Turku University Central Hospital, 20520 Turku, Finland

Branched-chain amino acids (BCAA) stimulate muscle and liver protein synthesis in vitro. The significance of this action in catabolic conditions in vivo remains controversial. The effects of a high supply of BCAA in total parenteral nutrition (TPN) on nitrogen balance and liver protein synthesis were studied in a postoperative rat model. After standard operative trauma TPN was commenced with one of two isocaloric programs (I: 20.1% BCAA and II: 50% BCAA) and continued for 48 hr. The relative rate of liver protein synthesis, measured after TPN in vitro by perfusion with 14C-leucine, was similar in both groups (I: 53.4 ± 17.3 and II: 49.0 ± 27.3 arbitrary units of synthesis rate, mean ± SD). The cumulative nitrogen balance was positive with both regimens and was not improved by the high supply of BCAA (I: 2.02 ± 0.81 and II: 1.87 ± 0.63 gN/kg/48 hr mean ± SD). We conclude that after moderate surgical trauma TPN with a high supply of BCAA offers no advantage over conventional TPN. (Journal of Parenteral and Enteral Nutrition 10:574-577, 1986)

Journal of Parenteral and Enteral Nutrition, Vol. 10, No. 6, 574-577 (1986)
DOI: 10.1177/0148607186010006574
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 JPEN J Parenter Enteral NutrHome page
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 JPEN J Parenter Enteral NutrHome page
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