This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Wei Jao Chen Search for Related Content PubMed PubMed Citation Articles by Wei Jao Chen, Social Bookmarking                         What's this?

Utilization of Intralipid in Septic Rats: Effects of Sepsis on the Clearance of Exogenous Fat Emulsion from Various Organs

Department of Surgery, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China

The rats were used for the study of the effects of sepsis on the utilization of exogenous fat emulsion. The studies were carried out by measuring the rate and the pattern of clearance of intravenously-administered ¹⁴C-Intralipid from the plasma, liver, spleen, kidney, and muscle of control and septic rats. Plasma clearance of the exogenous fat measured for ¹⁴C at 30, 60, 90, 120, 360 min (n = 5) after intravenous injection revealed that the clearance was retarded by sepsis. In the liver, the initial ¹⁴C uptake was much greater in the septic rats than those in the control group (34.8 ± 3.6% us 14.4 ± 1.6%, p < 0.01). Six hr after injection, as high as 19.6 ± 2.4% of the injected dose was detected in the liver of the septic rats, but the control rats had only 4.4 ± 0.8%. In spleen, kidney, and muscle, however, both the ¹⁴C uptake and the rate of its clearance were greater for the control rats than those of the septic group. The increase in the amount of liver uptake of the exogenous fat by the septic rat and the retained large amount of the fat may account for the decreased plasma clearance and the decrease in its subsequent utilization by other organs and tissues. Significant increase in liver contents of total lipid and triglyceride with a decrease in nonesterified fatty acid (NEFA) at the end of a 6-hr period in septic rats suggest that accumulation of fat in the liver may be a result of impaired triglyceride hydrolysis, possibly due to suppressed lipoprotein lipase activity. (Journal of Parenteral and Enteral Nutrition 10:482-486, 1986)

Journal of Parenteral and Enteral Nutrition, Vol. 10, No. 5, 482-486 (1986)
DOI: 10.1177/0148607186010005482


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				J. P. Grant Invited Review: Nutrition Care of Patients With Acute and Chronic Respiratory Failure Nutr Clin Pract, February 1, 1994; 9(1): 11 - 17. [Abstract] [PDF]