This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Harrie, K. R. Articles by Mcintosh, N. L. Search for Related Content PubMed PubMed Citation Articles by Harrie, K. R. Articles by Mcintosh, N. L. Social Bookmarking                         What's this?

Comparison of Total Nutrient Admixture Stability Using Two Intravenous Fat Emulsions, Soyacal and Intralipid 20%

California State University, Long Beach, Western Nutrition, Education, and Cancer Research Foundation, Woodland Hills, Alpha Therapeutic Corporation, Los Angeles, California

Mary Jacob, PH.D.

California State University, Long Beach, Western Nutrition, Education, and Cancer Research Foundation, Woodland Hills, Alpha Therapeutic Corporation, Los Angeles, California

David Mccormick, PHARM. D.

California State University, Long Beach, Western Nutrition, Education, and Cancer Research Foundation, Woodland Hills, Alpha Therapeutic Corporation, Los Angeles, California

John S. Reid, PHARM. D.

California State University, Long Beach, Western Nutrition, Education, and Cancer Research Foundation, Woodland Hills, Alpha Therapeutic Corporation, Los Angeles, California

Norma L. Mcintosh, PH.D., R.D.

California State University, Long Beach, Western Nutrition, Education, and Cancer Research Foundation, Woodland Hills, Alpha Therapeutic Corporation, Los Angeles, California

The safe clinical use and physical stability of a total nutrient admixture (TNA) system containing a soybean oil emulsion (Intralipid) has been reported. A study was conducted to compare the physical stability of four admixtures which were divided into two groups based upon the ratios (1:1:1 and 2:1:1) of amino acids (8.5%), dextrose (70%), and fat emulsion (20%). The fat component in each group contained either a new soy bean fat emulsion, Soyacal, or Intralipid. The quantities of all electrolytes, trace elements and vitamin additives were the same. All solutions were stored at 4°C for 28 days and then held at ambient temperature for 5 days for a total 33-day study period. Each admixture was serially analyzed on days 0, 1, 2, 3, 5, 7, 14, 21, 28, 29, 30, 31, 32, and 33. Examination of gross visual appearance and determinations of pH were performed. Osmolality was measured by means of freezing point depression (Advanced Digimatic Osmometer, Advanced Instruments, Inc., Needham Heights, MA). A Brook-haven particle analyzer was used to measure lipid particle size and particle size distribution. Electron and light microscopy were used to verify maximum particle size and distribution on days 0, 7, 14, 21, 28, and 29. The type of lipid emulsion used did not affect the pH or osmolality of the admixtures. Admixtures prepared with the 2:1:1 ratio had slightly higher pH (0.07) and lower osmolality (350 mOsm/kg). The range of mean diameters for the admixtures prepared with Soyacal and Intralipid were 0.283 to 0.310 µm and 0.314 to 0.351 µm, respectively. Based upon particle size distribution, 95% of all particles were less than 0.395 and 0.392 µm (Soyacal) and 0.444 and 0.439 µm (Intralipid). The largest particle observed in the admixture was 8.75 µm. Our data indicate that the physical stability of a TNA system prepared with Soyacal 20% or Intralipid 20% are similar. (Journal of Parenteral and Enteral Nutrition 10:381-387, 1986)

Journal of Parenteral and Enteral Nutrition, Vol. 10, No. 4, 381-387 (1986)
DOI: 10.1177/0148607186010004381


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				S. E. Hill, L. S. Heldman, E. D.H. Goo, P. E. Whippo, and J. C. Perkinson Fatal Microvascular Pulmonary Emboli From Precipitation of a Total Nutrient Admixture Solution JPEN J Parenter Enteral Nutr, January 1, 1996; 20(1): 81 - 87. [Abstract] [PDF]