|
Sign In to gain access to subscriptions and/or personal tools.
|
The Effect of a Pectin-Supplemented Elemental Diet on Intestinal Adaptation to Massive Small Bowel Resection
Mark J. Koruda, M.D.
Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
Rolando H. Rolandelli, M.D.
Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
R. Gregg Settle, PH.D.
Department of Otorhinolaryngology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
Scott H. Saul, M.D.
Department of Pathology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
John L. Rombeau, M.D.
Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
The effect of a pectin-supplemented elemental diet on intestinal adaptation to massive small bowel resection in the rat was investigated in this study. Sixty adult Sprague-Dawley rats underwent placement of a feeding gastrostomy and swivel apparatus. Control animals (N = 16) were then returned to their cages while the remaining animals underwent an 80% small bowel resection and anastomosis (resected, N = 44). Postoperatively, animals were randomly assigned to receive either a fat- and fiber-free elemental diet (no pectin) or the same diet supplemented with 2% pectin (pectin). After 8 days of full strength diet, samples of jejunum, ileum, and colon were obtained for analysis. The weights per unit length of the ileum and colon were significantly greater in the resected pectin group than either the resected no pectin or pectin control groups. Mucosal parameters (unit weight, DNA, RNA, and protein content) were significantly increased in the jejunum and ileum of both the resected pectin and resected no pectin groups relative to their respective control groups. However, jejunal and ileal mucosal parameters were significantly greater (1.3- to 2-fold) for the resected pectin group than for the resected no pectin group. All the mucosal parameters of the colons were significantly greater for the pectin resected group than for the pectin control group, while only colonic mucosal RNA was significantly greater for the no pectin resected group than for the no pectin control group. These data indicate that the addition of pectin to an elemental diet significantly enhanced intestinal adaptation to massive small bowel resection in the rat. (Journal of Parenteral and Enteral Nutrition 10: 343-350, 1986)
Journal of Parenteral and Enteral Nutrition, Vol. 10, No. 4,
343-350 (1986)
DOI: 10.1177/0148607186010004343
 CiteULike  Complore  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter What's this?
This article has been cited by other articles:
|
|
|
|
 
M. W. Schaart, A. C. J. M. de Bruijn, D. Tibboel, I. B. Renes, and J. B. van Goudoever
Dietary Protein Absorption of the Small Intestine in Human Neonates
JPEN J Parenter Enteral Nutr,
November 1, 2007;
31(6):
482 - 486.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A R Weale, A G Edwards, M Bailey, and P A Lear
Intestinal adaptation after massive intestinal resection
Postgrad. Med. J.,
March 1, 2005;
81(953):
178 - 184.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. R. Ziegler, C. F. Estivariz, C. R. Jonas, L. H. Gu, D. P. Jones, and L. M. Leader
Interactions Between Nutrients and Peptide Growth Factors in Intestinal Growth, Repair, and Function
JPEN J Parenter Enteral Nutr,
November 1, 1999;
23(6_suppl):
S174 - S183.
[Abstract]
[PDF]
|
|
|
|
|
|
|
H. Ehrlein and A. Stockmann
Absorption of Nutrients Is Only Slightly Reduced by Supplementing Enteral Formulas with Viscous Fiber in Miniature Pigs
J. Nutr.,
December 1, 1998;
128(12):
2446 - 2455.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
J. S. Thompson, E. M. Qugley, J.M. Palmer, W. W. West, and T. E. Adrian
Luminal Short-Chain Fatty Acids and Postresection Intestinal Adaptation
JPEN J Parenter Enteral Nutr,
September 1, 1996;
20(5):
338 - 343.
[Abstract]
[PDF]
|
|
|
|
|
|
|
W. L. Frankel, D. M. Choi, W. Zhang, J. A. Roth, S. H. Don, J. J. Afonso, F.-H. Lee, D. M. Klurfeld, and J. L. Rombeau
Soy Fiber Delays Disease Onset and Prolongs Survival in Experimental Clostridium difficile Ileocecitis
JPEN J Parenter Enteral Nutr,
January 1, 1994;
18(1):
55 - 61.
[Abstract]
[PDF]
|
|
|
|
|
|
|
I. Nordgaard-Andersen, M. R. Clausen, and P. B. Mortensen
Short-Chain Fatty Acids, Lactate, and Ammonia in Ileorectal and Ileal Pouch Contents: A Model of Cecal Fermentation
JPEN J Parenter Enteral Nutr,
July 1, 1993;
17(4):
324 - 331.
[Abstract]
[PDF]
|
|
|
|
|
|
|
H. Tamada, R. Nezu, Y. Matsuo, I. Imamura, Y. Takagi, and A. Okada
Alanyl Glutamine-Enriched Total Parenteral Nutrition Restores Intestinal Adaptation After Either Proximal or Distal Massive Resection in Rats
JPEN J Parenter Enteral Nutr,
May 1, 1993;
17(3):
236 - 242.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. M. Gottschlich
Invited Review: Selection of Optimal Lipid Sources in Enteral and Parenteral Nutrition
Nutr Clin Pract,
August 1, 1992;
7(4):
152 - 165.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A. Toki, T. Todani, Y. Watanabe, S. Uemura, Y. Sato, and Y. Morotomi
Effects of Pectin and Cellulose on Fat Absorption After Massive Small-Bowel Resection in Weanling Rats
JPEN J Parenter Enteral Nutr,
May 1, 1992;
16(3):
255 - 258.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D. Friedel and G. M. Levine
Effect of Short-Chain Fatty Acids on Colonic Function and Structure
JPEN J Parenter Enteral Nutr,
January 1, 1992;
16(1):
1 - 4.
[Abstract]
[PDF]
|
|
|
|
|
|
|
W. Scheppach, P. Bartram, A. Richter, F. Richter, H. Liepold, G. Dusel, G. Hofstetter, J. Ruthlein, and H. Kasper
Effect of Short-Chain Fatty Acids on the Human Colonic Mucosa in Vitro
JPEN J Parenter Enteral Nutr,
January 1, 1992;
16(1):
43 - 48.
[Abstract]
[PDF]
|
|
|
|
|
|
|
G. M. Levine and J. Rosenthal
Effects of Fiber-Containing Liquid Diets on Colonic Structure and Function in the Rat
JPEN J Parenter Enteral Nutr,
September 1, 1991;
15(5):
526 - 529.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. I. McBurney and L. U. Thompson
Dietary Fiber and Total Enteral Nutrition: Fermentative Assessment of Five Fiber Supplements
JPEN J Parenter Enteral Nutr,
May 1, 1991;
15(3):
267 - 270.
[Abstract]
[PDF]
|
|
|
|
|
|
|
P. P. Purdum III and D. F. Kirby
Review: Short-Bowel Syndrome: A Review of the Role of Nutrition Support
JPEN J Parenter Enteral Nutr,
January 1, 1991;
15(1):
93 - 101.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A. E. Barber, W. G. Jones II, J. P. Minei, T. J. Fahey III, L. L. Moldawer, J. L. Rayburn, E. Fischer, C. V. Keogh, G. T. Shires, and S. F. Lowry
Glutamine or Fiber Supplementation of a Defined Formula Diet: Impact on Bacterial Translocation, Tissue Composition, and Response to Endotoxin
JPEN J Parenter Enteral Nutr,
July 1, 1990;
14(4):
335 - 343.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. C. Palacio and J. L. Rombeau
Invited Review: Dietary Fiber: A Brief Review and Potential Application To Enteral Nutrition
Nutr Clin Pract,
June 1, 1990;
5(3):
99 - 106.
[PDF]
|
|
|
|
|
|
|
J. L. Rombeau
Nutritional Support: Service in Need of New Science
JPEN J Parenter Enteral Nutr,
September 1, 1989;
13(5):
445 - 449.
[PDF]
|
|
|
|
|
|
|
S. A. Kripke, A. D. Fox, J. M. Berman, R. G. Settle, and J. L. Rombeau
Stimulation of Intestinal Mucosal Growth with Intracolonic Infusion of Short-Chain Fatty Acids
JPEN J Parenter Enteral Nutr,
March 1, 1989;
13(2):
109 - 116.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D. M. Zimmaro, R. H. Rolandelli, M. J. Koruda, R. G. Settle, T. P. Stein, and J. L. Rombeau
Isotonic Tube Feeding Formula Induces Liquid Stool in Normal Subjects: Reversal by Pectina
JPEN J Parenter Enteral Nutr,
March 1, 1989;
13(2):
117 - 123.
[Abstract]
[PDF]
|
|
|
|
|
|
|
R. G. Settle
Invited Comment: Short-Chain Fatty Acids and Their Potential Role in Nutritional Support
JPEN J Parenter Enteral Nutr,
November 1, 1988;
12(6_suppl):
104S - 107S.
[PDF]
|
|
|
|
|
|
|
P. L. Beyer and D. C. Frankenfield
Enteral Nutrition in Extreme Short Bowel
Nutr Clin Pract,
April 1, 1987;
2(2):
60 - 64.
[PDF]
|
|
|
|
|
