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Journal of Parenteral and Enteral Nutrition
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Vitamin E Status in Patients on Parenteral Nutrition Receiving Intralipid

Michel G. Vandewoude

Department of Nutrition and Metabolism, University of Antwerp, Antwerp, Belgium

Maurits F.J. Vandewoude, M.D.

Department of Nutrition and Metabolism, University of Antwerp, Antwerp, Belgium

Ivo H. De Leeuw, PH.D.

Department of Nutrition and Metabolism, University of Antwerp, Antwerp, Belgium

Low vitamin E levels have been found to be a frequent side effect in patients on total parenteral nutrition (TPN). In the present study, the vitamin E content of fat emulsions (Intralipid) was measured and the influence of the intravenously administered lipid emulsion on plasma vitamin E levels was investigated. The majority of vitamin E was provided in the β + {gamma}-tocopherol fractions (68.7% of total tocopherol). Vitamin E levels in patients were significantly lower (p < 0.05) as compared to age- and sex-matched normal controls. Although sufficient amounts of vitamin E (16.9 ± 0.8 IU daily) were infused, according to RDA requirements, E-plasma levels decreased even further during the course of TPN. It was concluded that high amounts of biologically less active tocopherol isomers are not sufficient to maintain vitamin E plasma levels. Supplemental sources of {alpha}{alpha}-tocopherol are needed and more attention should be paid to the different tocopherol isomers in the quantitation of the daily allowances of vitamin E. (Journal of Parenteral and Enteral Nutrition 10:303-305, 1986)

Journal of Parenteral and Enteral Nutrition, Vol. 10, No. 3, 303-305 (1986)
DOI: 10.1177/0148607186010003303
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Home page
 JPEN J Parenter Enteral NutrHome page
F.J. Kelly and G.L.J. Sutton
Plasma and Red Blood Cell Vitamin E Status of Patients on Total Parenteral Nutrition
JPEN J Parenter Enteral Nutr, September 1, 1989; 13(5): 510 - 515.
[Abstract] [PDF]