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Journal of Parenteral and Enteral Nutrition
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Endocrine Mediators of Metabolism Associated with Injury and Sepsis

Michael S. Dahn, M.D.

Departments of Surgery, Nuclear Medicine, and Biochemistry, Veterans Administration Medical Center, and Wayne State University, Detroit, Michigan

Lloyd A. Jacobs, M.D.

Departments of Surgery, Nuclear Medicine, and Biochemistry, Veterans Administration Medical Center, and Wayne State University, Detroit, Michigan

M. Patricia Lange, B.S.N.

Departments of Surgery, Nuclear Medicine, and Biochemistry, Veterans Administration Medical Center, and Wayne State University, Detroit, Michigan

Stuart Smith, PH.D.

Departments of Surgery, Nuclear Medicine, and Biochemistry, Veterans Administration Medical Center, and Wayne State University, Detroit, Michigan

Robert A. Mitchell, PH.D.

Departments of Surgery, Nuclear Medicine, and Biochemistry, Veterans Administration Medical Center, and Wayne State University, Detroit, Michigan

We have studied the endocrine characteristics of 13 seriously ill patients with the use of a provocative intravenous glucose bolus. Notable in this stressed patient population was that no major interpatient differences in response to glucose were found for insulin, glucagon, cortisol, or epinephrine. However, following glucose challenge half of this group (7/13) exhibited a prominent "paradoxical" mean human growth hormone (hGH) elevation (26.4 ± 9.3 µU/ml) whereas the others (6/13) exhibited only a minor increase (7.8 ± 2.9 µU/ml). In addition, norepinephrine levels were significantly higher in the latter group suggesting that the adrenergic nervous system plays a major role in regulating hGH in stress. (Journal of Parenteral and Enteral Nutrition 10:253-257,1986)

Journal of Parenteral and Enteral Nutrition, Vol. 10, No. 3, 253-257 (1986)
DOI: 10.1177/0148607186010003253
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