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Journal of Parenteral and Enteral Nutrition
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Plasma and Erythrocyte Essential Fatty Acids during Total Parenteral Nutrition in Infants: Effects of a Cutaneous Supply

D. Bougle, M.D.

Unite de Gastroentérologie pediatrique et de nutrition, Hopital des Enfants Malades

D. Pepin, PH.D.

Laboratoire de Biochimie, Docteur Berezia, Foculté Saint-Antoine

M. Delhaye, PH.D.

Laboratoire Sopharga, Tour Roussel-Nobel, Paris, France

J. Chambaz, M.D.

Laboratoire de Biochimie, Docteur Berezia, Foculté Saint-Antoine

C. Ricour, M.D.

Unite de Gastroentérologie pediatrique et de nutrition, Hopital des Enfants Malades

In order to prevent essential fatty acid (EFA) deficiency induced by fat-free total parenteral nutrition (TPN), 10 infants on TPN were rubbed three times daily for 20 days using oenethera oil (80% EFA). Total EFA amount provided cutaneously was 1900 mg/kg/d. Plasma and red blood cells phospholipids were determined on days 1 and 20 in these 10 treated and six untreated infants on TPN and compared with those of normal control infants. On day 1, plasma nonessential FA including 20:3 n-9(p < 0.01) were increased in both TPN groups while 18:2 n-6 and and 18:3 n-3 (p < 0.001 and p < 0.01) were decreased. On the 20th day, EFA deficiency had worsened with a decrease in plasma level of 20:4 n-6 (p < 0.02) and a higher than normal triene/tetraene ratio : 3.4±1.1 and 2.3±0.6 us 0.1±0.1 (p < 0.02). As for red blood cells phospholipids, 16:0 was increased and 18:2 n-6 and 20:3 n-6 were decreased (p < 0.05) on day 1. On day 20, these FA were more abnormal while 20:3 n-9 became significantly increased (p < 0.05). No difference was observed between the TPN groups at any time. These results show that cutaneous application of large amounts of EFA-rich oil is unable to prevent or cure TPN induced EFA deficiency. (Journal of Parenteral and Enteral Nutrition 10:216-219, 1986)

Journal of Parenteral and Enteral Nutrition, Vol. 10, No. 2, 216-219 (1986)
DOI: 10.1177/0148607186010002216
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Home page
 Nutr Clin PractHome page
M. Shapiro and G. H. Rosen
Topical Oil Applications in Essential Fatty Acid Deficiency
Nutr Clin Pract, August 1, 1989; 4(4): 140 - 144.
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