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Aluminum Does Not Accumulate in Teenagers and Adults on Prolonged Parenteral Nutrition Containing Free Amino Acids

Departments of Pediatrics, Surgery and Medicine, University of California School of Medicine, San Francisco, California, Division of Pediatrics, City of Hope National Medical Center, Duarte, California, Department of Medicine, Creighton University School of Medicine, Omaha, Nebraska, Medical and Research Services, Veterans Administration Medical Center and Department of Medicine, University of Washington School of Medicine, Seattle, Washington, Medical and Research Seruices, Veterans Administration Medical Center and the Department of Medicine, University of Colorado School of Medicine, Denver, Colorado

Gordon L. Klein, M.D., M.P.H.

Departments of Pediatrics, Surgery and Medicine, University of California School of Medicine, San Francisco, California, Division of Pediatrics, City of Hope National Medical Center, Duarte, California, Department of Medicine, Creighton University School of Medicine, Omaha, Nebraska, Medical and Research Services, Veterans Administration Medical Center and Department of Medicine, University of Washington School of Medicine, Seattle, Washington, Medical and Research Seruices, Veterans Administration Medical Center and the Department of Medicine, University of Colorado School of Medicine, Denver, Colorado

Alvin Wong, PHARM. D.

Departments of Pediatrics, Surgery and Medicine, University of California School of Medicine, San Francisco, California, Division of Pediatrics, City of Hope National Medical Center, Duarte, California, Department of Medicine, Creighton University School of Medicine, Omaha, Nebraska, Medical and Research Services, Veterans Administration Medical Center and Department of Medicine, University of Washington School of Medicine, Seattle, Washington, Medical and Research Seruices, Veterans Administration Medical Center and the Department of Medicine, University of Colorado School of Medicine, Denver, Colorado

Robert R. Recker, M.D.

Departments of Pediatrics, Surgery and Medicine, University of California School of Medicine, San Francisco, California, Division of Pediatrics, City of Hope National Medical Center, Duarte, California, Department of Medicine, Creighton University School of Medicine, Omaha, Nebraska, Medical and Research Services, Veterans Administration Medical Center and Department of Medicine, University of Washington School of Medicine, Seattle, Washington, Medical and Research Seruices, Veterans Administration Medical Center and the Department of Medicine, University of Colorado School of Medicine, Denver, Colorado

J. Blake Tyrrell, M.D.

Departments of Pediatrics, Surgery and Medicine, University of California School of Medicine, San Francisco, California, Division of Pediatrics, City of Hope National Medical Center, Duarte, California, Department of Medicine, Creighton University School of Medicine, Omaha, Nebraska, Medical and Research Services, Veterans Administration Medical Center and Department of Medicine, University of Washington School of Medicine, Seattle, Washington, Medical and Research Seruices, Veterans Administration Medical Center and the Department of Medicine, University of Colorado School of Medicine, Denver, Colorado

Allen C. Alfrey, M.D.

Departments of Pediatrics, Surgery and Medicine, University of California School of Medicine, San Francisco, California, Division of Pediatrics, City of Hope National Medical Center, Duarte, California, Department of Medicine, Creighton University School of Medicine, Omaha, Nebraska, Medical and Research Services, Veterans Administration Medical Center and Department of Medicine, University of Washington School of Medicine, Seattle, Washington, Medical and Research Seruices, Veterans Administration Medical Center and the Department of Medicine, University of Colorado School of Medicine, Denver, Colorado

Donald J. Sherrard, M.D.

Departments of Pediatrics, Surgery and Medicine, University of California School of Medicine, San Francisco, California, Division of Pediatrics, City of Hope National Medical Center, Duarte, California, Department of Medicine, Creighton University School of Medicine, Omaha, Nebraska, Medical and Research Services, Veterans Administration Medical Center and Department of Medicine, University of Washington School of Medicine, Seattle, Washington, Medical and Research Seruices, Veterans Administration Medical Center and the Department of Medicine, University of Colorado School of Medicine, Denver, Colorado

David C. Hohn, M.D.

Departments of Pediatrics, Surgery and Medicine, University of California School of Medicine, San Francisco, California, Division of Pediatrics, City of Hope National Medical Center, Duarte, California, Department of Medicine, Creighton University School of Medicine, Omaha, Nebraska, Medical and Research Services, Veterans Administration Medical Center and Department of Medicine, University of Washington School of Medicine, Seattle, Washington, Medical and Research Seruices, Veterans Administration Medical Center and the Department of Medicine, University of Colorado School of Medicine, Denver, Colorado

Prolonged total parenteral nutrition (TPN) with solutions containing hydrolyzed casein has been associated with aluminum accumulation in patients with bone disease. We investigated the effects of free amino acids in TPN solution on plasma, urine, and bone aluminum in six patients, five of whom had symptoms of bone disease or documented demineralization. No evidence of aluminum accumulation was found. TPN with free amino acids, containing 42 µg aluminum per liter or less, does not lead to aluminum loading in adolescents or adults. ( Journal of Parenteral and Enteral Nutrition 10:86-87, 1986)

Journal of Parenteral and Enteral Nutrition, Vol. 10, No. 1, 86-87 (1986)
DOI: 10.1177/014860718601000186


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