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Tumor Immunogenicity—The Prime Determinant of the Nutritional Influence on the Host-Tumor Relationship

Department of Surgery and the Joseph Stokes, Jr., Research Institute, The Children's Hospital of Philadelphia, Department of Surgery, Harrison Department of Surgical Research, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

Craig B. Ikeda

Department of Surgery and the Joseph Stokes, Jr., Research Institute, The Children's Hospital of Philadelphia, Department of Surgery, Harrison Department of Surgical Research, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

Moritz M. Ziegler, M.D.

Department of Surgery and the Joseph Stokes, Jr., Research Institute, The Children's Hospital of Philadelphia, Department of Surgery, Harrison Department of Surgical Research, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

The influence which malnutrition plays on the host-tumor relationship is controversial because of the disparity of human and rodent tumors, a critical difference being the minimal immuogenicity of human tumors and the variable antigenicity of rodent tumors. The hypothesis we tested is that the influence of malnutrition on tumor growth is a result of the immunogenicity of the host's tumor. C-1300 neuroblastoma (NB) is an immunogenic tumor by in vivo and in vitro assessment while the histologically identical TBJ-NB clone is non-immunizing. Isogeneic A/J mice were malnourished with 2.5% protein chow and were inoculated with C-1300-NB or TBJ-NB; either serial tumor volumes were assessed by three-dimensional measurement or animals were serially killed and tumor weight/carcass weight ratios (TW/CW) were calculated. Non-immunogenic TBJ-NB grew more rapidly than C-1300-NB in both control and malnourished groups, but there was no difference in either tumor size or TW/CW ratios between the two TBJ-NB nutritional groups. Contrasting with these data were immunogenic C-1300-NB in that the tumor grew significantly better in malnourished mice (tumor volume p < 0.05 day 12 and 14; TW/CW p < 0.026 by day 21). Prior whole-body irradiation abrogated this difference. These data demonstrate that for tumors differing only in antigenicity the influence of malnutrition is on that tumor which induces an immunologic antitumor response. (Journal of Parenteral and Enteral Nutrition 10:21-28, 1986)

Journal of Parenteral and Enteral Nutrition, Vol. 10, No. 1, 21-28 (1986)
DOI: 10.1177/014860718601000121


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